This article came up in a search as mentioning "Chronic Fatigue Syndrome" and I'm curious to know what was said:
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An A Poteliakhoff wrote this article:
Alex Poteliakhoff: campaigner for a less violent world.
Poteliakhoff A, Watts G.
Lancet. 2015 May 30;385(9983):2143. doi: 10.1016/S0140-6736(15)61012-1. No abstract available.
PMID: 26068256 [PubMed - indexed for MEDLINE]
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Alex Poteliakhoff is not keen on email so I use his letter box to deliver the note inviting him to be profiled. I follow it up with a phone call. Yes, he'd be honoured—but can he be clear that what's intended is indeed a profile, not an obituary. The query, although humorously intended, makes a point. Although he could be taken for a man 15 years younger, Poteliakhoff will celebrate his 97th birthday this year. “My brain functions rather slowly, and I do forget things”, he insists when I meet him a few days later at his home in London.
An A Poteliakhoff wrote this article:
Original Article
Fatigue Syndromes and the Aetiology of Autoimmune Disease
1998, Vol. 4, No. 4 , Pages 31-49
A. Poteliakhoff
A. Poteliakhoff is a retired Hospital and General Practice Physician. Sudbury, 16 B Prince Arthur Road, London NW3 6AY, UK.
Abstract
In the last decade or so, an impairment of Hypolhalamic-Pituitary-Adrenal (HPA) axis activity has been observed in fatigue syndromes. Elevated levels of glucocorticoids help to prevent the immune system from over-reacting and generating a damaging autoimmune process. The corollary should be that reduced activity of the HPA axis and diminished levels of plasma corlisol could be associated with autoimmune (AI) disease. Experimental work in mice and rats supports this view. Furthermore, plasma levels of cortisol have been found to be low in the early stages of rheumatoid arthritis. There is some clinical evidence that connective tissue disorders (many of which are regarded as autoimmune diseases) occur approximately one year after the onset of prolonged or chronic fatigue, with the implication that fatigue is not merely a symptom of these disorders but precedes them. Many workers have found changes in the immune system of subjects suffering from CFS (mainly immune activation) which could be conducive to the development of AI disease. It has recently been found that there is, in the CFS, some deficiency of another adrenal steroid, namely that of dehydroepiandrosterone. This steroid exerts a regulatory activity on the immune system and a deficiency may well be an additional factor in the genesis of AI disease.
If an association can be established between fatigue syndromes and autoimmune disease then these syndromes will need to be addressed in a more concerned manner and prophylactic measures undertaken to forestall AI disease.
Keywords
Fatigue syndromes, cortisol, dehydroepiandrosterone (prasterone), immune activation, autoimmune disease
Read More: http://informahealthcare.com/doi/abs/10.1300/J092v04n04_04
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