Hip
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A new study found that 65% of people attending an IBS clinic also have ME/CFS.
The study found too that 86% of IBS patients had extensive antibiotics as a child, and the study authors suggest the antibiotic depletion of Lactobacillus friendly bacteria may have set the scene for IBS.
I can attest to extensive childhood antibiotics (for chronic tonsillitis). Then I developed IBS at around 33 years old, and about 9 years after getting IBS, I came down with ME/CFS from a viral infection.
Antibiotic Depletion Of Lactobacillus Bacteria the Root of the Problem?
The study authors say there are several possibilities for how IBS may lead to symptoms outside the gastrointestinal tract, but that they would like to focus on the theory that antibiotic induced depletion of Lactobacillus friendly bacteria may promote overgrowth of other bacteria as well as Candida albicans within a biofilm in the small intestine — ie, promote small intestinal bacterial overgrowth (SIBO).
The authors say in planktonic form, Candida albicans is an innocent commensal organism of the mouth and the GI tract. However, planktonic yeast may turn to more virulent hyphal forms, particularly when forming biofilms, and when there is lack of Lactobacillus or a diverse anaerobic bacteria in the colon.
Hyphal forms of Candida are known to seriously modify the innate immunity, and impair intestinal barrier function enabling systemic dissemination of yeast. Thus, the authors suggest, a shortage of intestinal Lactobacillus may be a major cause of Candida-induced gastrointestinal inflammation and systemic symptoms in patients with IBS.
Could Tryptophan Help Replenish the Lactobacillus Bacteria?
The authors say that taking Lactobacillus probiotics seems like a logical approach, but say Lactobacillus probiotics do not colonize the human gut — and such probiotics may even kill the existing friendly bacteria in your gut. (Maybe this might explain why some ME/CFS patients feel worse on probiotics).
However, since most Lactobacilli require L-tryptophan for their growth, the authors suggest an alternative approach could be to stimulate the growth of the existing Lactobacillus in the gut by feeding them with tryptophan, or preferably tryptophan-rich bioactive peptides made from milk proteins.
Other researchers have shown that in mice, recovery of Lactobacillus populations, as well as suppression of Candida, is achieved by oral administration of tryptophan. So tryptophan might be a good food for increasing Lactobacillus population in the gut.
The study found too that 86% of IBS patients had extensive antibiotics as a child, and the study authors suggest the antibiotic depletion of Lactobacillus friendly bacteria may have set the scene for IBS.
I can attest to extensive childhood antibiotics (for chronic tonsillitis). Then I developed IBS at around 33 years old, and about 9 years after getting IBS, I came down with ME/CFS from a viral infection.
Antibiotic Depletion Of Lactobacillus Bacteria the Root of the Problem?
The study authors say there are several possibilities for how IBS may lead to symptoms outside the gastrointestinal tract, but that they would like to focus on the theory that antibiotic induced depletion of Lactobacillus friendly bacteria may promote overgrowth of other bacteria as well as Candida albicans within a biofilm in the small intestine — ie, promote small intestinal bacterial overgrowth (SIBO).
The authors say in planktonic form, Candida albicans is an innocent commensal organism of the mouth and the GI tract. However, planktonic yeast may turn to more virulent hyphal forms, particularly when forming biofilms, and when there is lack of Lactobacillus or a diverse anaerobic bacteria in the colon.
Hyphal forms of Candida are known to seriously modify the innate immunity, and impair intestinal barrier function enabling systemic dissemination of yeast. Thus, the authors suggest, a shortage of intestinal Lactobacillus may be a major cause of Candida-induced gastrointestinal inflammation and systemic symptoms in patients with IBS.
Could Tryptophan Help Replenish the Lactobacillus Bacteria?
The authors say that taking Lactobacillus probiotics seems like a logical approach, but say Lactobacillus probiotics do not colonize the human gut — and such probiotics may even kill the existing friendly bacteria in your gut. (Maybe this might explain why some ME/CFS patients feel worse on probiotics).
However, since most Lactobacilli require L-tryptophan for their growth, the authors suggest an alternative approach could be to stimulate the growth of the existing Lactobacillus in the gut by feeding them with tryptophan, or preferably tryptophan-rich bioactive peptides made from milk proteins.
Other researchers have shown that in mice, recovery of Lactobacillus populations, as well as suppression of Candida, is achieved by oral administration of tryptophan. So tryptophan might be a good food for increasing Lactobacillus population in the gut.
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