Trial HBOT

SWAlexander

SWAlexander

Senior Member
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2,076

Trial description​

Observational study aimed at assessing the improvement of physical function measured by the SF-36 after Hyperbaric Oxygen Therapy (HBOT) in patients with Post-COVID Syndrome and ME/CFS

ME/CFS is a widespread and profoundly debilitating condition. Those affected experience extreme fatigue, concentration difficulties, headaches, and other symptoms even with minimal physical and mental activity. ME/CFS is frequently observed even after COVID-19.
Current research suggests that Hyperbaric Oxygen Therapy (HBOT), currently being globally investigated as a therapeutic approach for Post-COVID Syndrome, could be an effective treatment. In two open-label studies and one placebo-controlled study, it was demonstrated that HBOT notably improved neurocognitive symptoms in Post-COVID patients. The presumed mechanism of action involves improving blood circulation, promoting capillary formation, and exerting a positive influence on the immune system function.
Based on this evidence, HBOT is already offered as a therapeutic procedure for Post-COVID Syndrome and ME/CFS in many centers in Germany for self-pay patients. The aim of our study is to investigate whether HBOT leads to long-term improvement in physical limitations in patients with ME/CFS.
HBOT will be administered on an outpatient basis, five days a week, over a period of 8 weeks in cooperation with the Vivantes Klinikum Friedrichshain. Treatment response will be assessed using questionnaires, measurements of muscle strength and cardiovascular function, as well as biomarkers.
A total of 60 participants will be enrolled in the study. Only patients who have previously participated in our observational studies can be included in the study. https://cfc.charite.de/en/clinical_research/nksg/trial_hbot/
 
mattie

mattie

Senior Member
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384
Interesting.

HBOT is also offered Off-Label here in the Netherlands for Long Covid patients and they claim some decent results.
https://hgcrijswijk.nl/behandeling-van-long-covid-met-hyperbare-zuurstoftherapie/
and
https://www.hyperbaarcentrum.nl/zuurstoftherapie-bij-long-covid/

Treatment is same protocol as the Berlin trial:
5 days a week,
3 sessions of 20 minutes with 5 minute breaks
100% oxygen is breathed at 2.4 atmospheres
For a total of 8 weeks.
Costs: 210,97 per session

Note that this therapy is very different from `'oxygen therapy" in vessels that provide only 1,5 ATM or even less and oxygen from a concentrator providing 95% O2 at max. Also medical supervision is recommended as it is not entirely without risks.

Hope that trial in Berlin shows about the same promising results as seen in LC patients.
I'd sure like to try the 8 week treatment. Have to sort out the logistics around that.

Hyperbaric oxygen therapy improves neurocognitive functions and symptoms of post‑COVID condition: randomized controlled trial

hgc-rijswijk-zuurstoftank-max-w800.jpg
 
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SWAlexander

SWAlexander

Senior Member
Messages
2,076
Thank you mattie, I wish I could try it out, but unfortunately, I have no way to get there.
About four years ago, I theorized that the principal 'oxidant' pressure chambers used in polio treatments might have the potential to restore muscle activity—possibly even for individuals with SMA.
 
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D

dankeen

Messages
39
Although it did nothing for me then HBOT helps a significant minority of patients. The problems are the high cost and for anyone worse than mild-moderate the exertion of turning up five days a week for at least four weeks.
 
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