J.G
Senior Member
- Messages
- 162
I wonder about the fringe conditions here. Under what circumstances can DCA temporarily "override" the wrongly flicked metabolic switch? (For I don't think it flicks the switch back, because that would be a permanent cure - unless, of course, some process then ends up flicking it back again.) Does it work where the cause is epigenetic? Where autoantibodies are at play? Where the cause is a positive feedback loop, metabolic or otherwise? Where there are sufficiently sequestered resources to break out of the "altered state" when the switch is overridden? And what if there are not?Yes. If you examine Ron Davis and Naviaux research you will see that they somehow support the idea that some of the ME/CSF cases could be related to mitochondrial disfunction and Sodium dichloroacetate mainly affects the mitochondria. It sort of "revives" them and enables adequate energy production again.
I personally can override the metabolic bottleneck with a freezing cold shower, but the "hey I feel much better"-effect only lasts for about 45mins and still gives me bad PEM on exertion, presumably because I still rely on lactate-producing glycolysis for energy, just a higher rate of it. (Cold exposure increases the metabolic rate through a process called cold thermogenesis, if I understand it correctly.) I wonder if DCA would do anything for me. I'm terrified to try, though. If I get any worse, my life will be over entirely.
Last edited: