Wayne
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I found the following very concise and helpful, so thought I'd share it here...
What is Trauma-Based Nervous System Dysregulation?
How This Relates to ME/CFS
Trauma as a Root, Trigger, or Amplifier
Key Connection Points

Trauma-based nervous system dysregulation refers to the idea that traumatic experiences — whether acute or chronic, physical or emotional — can cause the autonomic nervous system (ANS) to shift into a prolonged state of dysregulation.
The ANS is responsible for regulating things like:
- Heart rate
- Breathing
- Digestion
- Immune function
- Stress response (via the sympathetic and parasympathetic systems)
When the nervous system is healthy, it’s flexible — it can shift smoothly between “fight/flight,” “rest/digest,” and “freeze” modes. But trauma — especially chronic, early, or unresolved trauma — can lock a person into a dysregulated pattern. This can look like:
- Hypervigilance or anxiety (sympathetic overactivation)
- Shutdown, fatigue, or numbness (dorsal vagal dominance)
- A constant swing between both (which can feel like unpredictability or emotional fragility)

ME/CFS (Myalgic Encephalomyelitis / Chronic Fatigue Syndrome) is a complex, multisystem illness with hallmark symptoms like:
- Post-exertional malaise (PEM)
- Unrefreshing sleep
- Cognitive dysfunction (“brain fog”)
- Autonomic instability (POTS, temperature dysregulation)
- Immune and inflammatory dysfunction
There’s growing evidence that nervous system dysregulation is a core driver or amplifier of ME/CFS symptoms. Here’s how trauma plays in:

- As a Root Cause: Some people with ME/CFS have histories of trauma (childhood adversity, neglect, illness, surgeries, emotional abuse). These experiences may prime the nervous system into a long-term dysregulated state, reducing resilience and making them more vulnerable to later illness.
- As a Trigger: For others, ME/CFS begins after a severe infection (e.g., Epstein-Barr, COVID, Lyme), but pre-existing trauma can affect how the body responds to that trigger, influencing the severity or chronicity of symptoms.
- As an Amplifier: Living with ME/CFS is traumatic in itself — the loss of function, misunderstanding by doctors, social isolation, and financial insecurity can deepen nervous system dysfunction, creating a vicious cycle.

- Dysregulated vagus nerve function is common in both trauma and ME/CFS — affecting heart rate variability, digestion, inflammation, and immune response.
- Neuroinflammation and glial activation (seen in both chronic stress and ME/CFS) can impair brain function and increase pain sensitivity.
- Hypersensitivities to light, sound, chemicals, and possibly EMFs are features of both trauma-related disorders (like PTSD) and ME/CFS.
- Energy metabolism may be disrupted in both trauma states and ME/CFS — affecting mitochondrial function, fatigue, and recovery.