Tramadol is not regarded well in our family.
One pill sent my sister crawling up the walls for three days. Never again, she said. But she is also very sensitive to anything and everything. She had MCS back in the 1970s before it was a thing.
I tolerate all drugs and everything well. But Tramadol: after a few days of just one at night, the result was lots of tears, anxiety, overheating, blurry vision, and a slight dizziness - the bumping into the hall wall on occasion.
That said, it gave excellent post-operative pain relief. But the pain was a better and less scary option.