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Prevalence of thyroid dysfunction and its correlation with CD4 count in newly-diagnosed HIV-positive adults – a cross-sectional study
2014
Abstract
Prevalence of subclinical hypothyroidism in HIV-positive patients is reported to be high in those with severe immune deficiency.
However, there is paucity of literature in newly-diagnosed HIV-positive population.
Our aim was to estimate the prevalence of thyroid dysfunction and study its correlation with CD4 count in this population.
In this cross-sectional study, patients presenting to the antiretroviral therapy clinic were screened with thyroid function tests, including thyroid stimulating hormone, free triiodothyronine, free thyroxine, and anti-thyroid peroxidase antibody levels at the time of diagnosis.
Two hundred and twenty-five HIV-positive and an equal number of healthy volunteers were enrolled.
The mean (SD) CD4 count in the study group was 147.1 (84) and 70.7% had advanced immune deficiency with CD4 count <200 cells/µL.
The overall prevalence of thyroid dysfunction was 75.5% in the study group and 16% in the control group.
Subclinical hypothyroidism was the commonest abnormality noted in almost 53%.
Significant correlation was observed between CD4 count and thyroid stimulating hormone, free triiodothyronine, and free thyroxine levels (r = −0.86, r = 0.77, and r = 0.84, respectively, p < 0.0001 for all).
The present study demonstrated high prevalence of thyroid dysfunction in HIV-positive patients.
The dysfunction is subclinical in most cases and correlates well with declining CD4 counts.
2014
Abstract
Prevalence of subclinical hypothyroidism in HIV-positive patients is reported to be high in those with severe immune deficiency.
However, there is paucity of literature in newly-diagnosed HIV-positive population.
Our aim was to estimate the prevalence of thyroid dysfunction and study its correlation with CD4 count in this population.
In this cross-sectional study, patients presenting to the antiretroviral therapy clinic were screened with thyroid function tests, including thyroid stimulating hormone, free triiodothyronine, free thyroxine, and anti-thyroid peroxidase antibody levels at the time of diagnosis.
Two hundred and twenty-five HIV-positive and an equal number of healthy volunteers were enrolled.
The mean (SD) CD4 count in the study group was 147.1 (84) and 70.7% had advanced immune deficiency with CD4 count <200 cells/µL.
The overall prevalence of thyroid dysfunction was 75.5% in the study group and 16% in the control group.
Subclinical hypothyroidism was the commonest abnormality noted in almost 53%.
Significant correlation was observed between CD4 count and thyroid stimulating hormone, free triiodothyronine, and free thyroxine levels (r = −0.86, r = 0.77, and r = 0.84, respectively, p < 0.0001 for all).
The present study demonstrated high prevalence of thyroid dysfunction in HIV-positive patients.
The dysfunction is subclinical in most cases and correlates well with declining CD4 counts.