frozenborderline
Senior Member
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https://en.m.wikipedia.org/wiki/GABA_analogue#GABA_prodrugs
This whole Wikipedia page is great and way more fruitful than I would’ve thought
First thought —what is with the Soviets and really interesting gaba prodrugs that have a broad range of protective effects?
Second thought: https://en.m.wikipedia.org/wiki/Isovaline
What the heck ??? “Isovaline is a rare amino acidtransported to earth by the Murchison meteorite, which landed in Australia in 1969. The discovery of isovaline in the biosphere demonstrates an extraterrestrial origin of amino acids and has been linked to the homochirality of life on earth [1] suggesting a role in the origin of life.[2]...
The structure of isovaline is similar to the amino acids GABA and glycine, the chief inhibitory neurotransmitters in the mammalian central nervous system. Isovaline acts as an analgesic in mice [3][4] by activating peripheral GABABreceptors.[4][5] In a mouse model of osteoarthritis isovaline restored mobility, suggesting inhibition of nociception by isovaline in the synovial membrane of the mouse knee.[4]”
[FONT=Helvetica Neue, Helvetica, Nimbus Sans L, Arial, Liberation Sans, sans-serif]There are lots of really interesting and possibly helpful compounds on this page although I don’t know where one would source some of them. @Hip you May find this interesting [/FONT]
This whole Wikipedia page is great and way more fruitful than I would’ve thought
First thought —what is with the Soviets and really interesting gaba prodrugs that have a broad range of protective effects?
Second thought: https://en.m.wikipedia.org/wiki/Isovaline
What the heck ??? “Isovaline is a rare amino acidtransported to earth by the Murchison meteorite, which landed in Australia in 1969. The discovery of isovaline in the biosphere demonstrates an extraterrestrial origin of amino acids and has been linked to the homochirality of life on earth [1] suggesting a role in the origin of life.[2]...
The structure of isovaline is similar to the amino acids GABA and glycine, the chief inhibitory neurotransmitters in the mammalian central nervous system. Isovaline acts as an analgesic in mice [3][4] by activating peripheral GABABreceptors.[4][5] In a mouse model of osteoarthritis isovaline restored mobility, suggesting inhibition of nociception by isovaline in the synovial membrane of the mouse knee.[4]”
[FONT=Helvetica Neue, Helvetica, Nimbus Sans L, Arial, Liberation Sans, sans-serif]There are lots of really interesting and possibly helpful compounds on this page although I don’t know where one would source some of them. @Hip you May find this interesting [/FONT]
