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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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Interesting read. Drugs that act on the nervous system poop out for me after some time (Insidon, Vagantin...) . Didn’t make a COMPT test?! Is it expensive?Of course this is only based on my own experience and I really have very little scientific understanding, but thought it was atleast worth mentioning/discussing.
I have not tried ablify but I did experience poop out with ritalin.
It seems fairly established that ME causes some kind of low dopamine state (or maybe the low dopamine state causes the ME? Who knows)
BUT what about COMT gene status?
I have COMT met/met mutation which means I generally have a high dopamine (as I can’t break it down well) and can perform very well if not under stress - this might explain why cognitively I’m better off than many.
If you had COMT Val/Val this will likely contribute to the low dopamine state potentially making you iller than the met/met type.
My thoughts are that if you have COMT met/met like me you are constantly swinging between high and low dopamine which would mean dopaminergic drugs may not be as effective and could actually build too high levels of dopamine causing issues like rage (which I get) it could also be the cause of poop out because we end up with too high dopamine levels causing us to push too hard and crash then reducing the positive action of the drug.
But if you have the COMT Val/Val maybe the drugs were less likely to poop out because your dopamine wouldn’t get too high causing you to push and ruin the positive effect of the drug?
Is it saliva? Because that’s again a factor for artefactsRight I thought we just wanted what I have above. The ones I screenshotted are 23andme.
If you want the whole genome it costs about £600. I think Dante still do WGS whole genome sequencing. £600 is a 30x pass so that would get you a decent level of accuracy for all genes.