Viral Connection, NAD synthesis: Kynurenine Pathway
Viruses can affect the NAD Synthesis in the Kynurenine pathway. We know quinolinic and interferon gamma are elevated in the majority CFS/ME subgroups. The NAD+ deficiency is a contributing factor in the CFS/ME progression. The main critical concern is the NADH recycling anaerobic metabolism (ADP to ATP) imbalance. This is the reason why it's import to supplement to bypass the weak NAD synthesis. Nicotinamide, NAD, NADH, R- lipoic acid can compensate for the NAD+ deficiency. Riboflavin is needed for the monoamine oxidase enzyme, which functions in this metabolism.
Kynurenine Pathway Metabolites in Humans: Disease and Healthy States
http://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=2&ved=0CDgQFjAB&url=http://www.la-press.com/redirect_file.php?fileId=1868&filename=IJTR-2-Guillemin-et-al&fileType=pdf&ei=M3HLUtauJobfsASmpoLQDQ&usg=AFQjCNFEpPCWbRBqRfKZX3PYzI2IcmtFlg&sig2=BdUNdAknPb76k-zC9PLmzQ&bvm=bv.58187178,d.cWc
NAD Synthesis
http://en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleotide
THE FATE OF PYRUVATE
http://www.hippocampus.org/homework-help/Biology/Central Catabolic Pathways_The Fate of
Pyruvate and NADH.html
Viruses can affect the NAD Synthesis in the Kynurenine pathway. We know quinolinic and interferon gamma are elevated in the majority CFS/ME subgroups. The NAD+ deficiency is a contributing factor in the CFS/ME progression. The main critical concern is the NADH recycling anaerobic metabolism (ADP to ATP) imbalance. This is the reason why it's import to supplement to bypass the weak NAD synthesis. Nicotinamide, NAD, NADH, R- lipoic acid can compensate for the NAD+ deficiency. Riboflavin is needed for the monoamine oxidase enzyme, which functions in this metabolism.
Kynurenine Pathway Metabolites in Humans: Disease and Healthy States
http://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=2&ved=0CDgQFjAB&url=http://www.la-press.com/redirect_file.php?fileId=1868&filename=IJTR-2-Guillemin-et-al&fileType=pdf&ei=M3HLUtauJobfsASmpoLQDQ&usg=AFQjCNFEpPCWbRBqRfKZX3PYzI2IcmtFlg&sig2=BdUNdAknPb76k-zC9PLmzQ&bvm=bv.58187178,d.cWc
NAD Synthesis
http://en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleotide
THE FATE OF PYRUVATE
http://www.hippocampus.org/homework-help/Biology/Central Catabolic Pathways_The Fate of
Pyruvate and NADH.html
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