SWAlexander
Senior Member
- Messages
- 1,519
As I said over a year ago:
Lack of or damaged prostaglandin leads to thrombosis.
Despite test evidence, doctors ignored for 2 years, my low cortisol. Further ignored existing VWF. How many people are tested for VWF, thrombosis and cortisol?
If you can, please read it all.
This is the second in a series of blogs on the IACFS/ME 2022 International Conference on ME/CFS (and long COVID). The last one focused on David Systrom’s Keynote address (https://www.healthrising.org/blog/2022/07/29/systrom-keynote-iacfs-me-conference-long-covid/. This one focused on an hour-long talk that kicked off the keynote session.
excerpt:
Chronic Fatigue Syndrome (ME/CFS) and Fibromyalgia Connection
Interest in the HPA axis – which regulates the production of cortisol – in ME/CFS dates back 30 years. While the cause of the low morning salivary cortisol was never identified, several problems in the HPA axis did pop up over time.
Several factors made the HPA axis and cortisol an obvious early choice. Cortisol’s regulation of the stress response, metabolism, the sleep-wake cycle, and in suppressing inflammation means it has the potential to affect many of the processes at play in ME/CFS and long COVID. While HPA axis work declined over time, in ME/CFS it never really stopped. One intriguing 2018 ME/CFS study linked epigenetic modifications in T-cells to an impaired response to glucocorticoid hormones, such as cortisol, in a subset of patients. Dr. Klimas’s model-generated protocol for Gull War Illness (GWI) and ME/CFS includes both an immune modulator (etanercept) and drug (mifepristone) that she hopes will reset the HPA axis.
https://www.healthrising.org/blog/2...ng-covid-factor-chronic-fatigue-fibromyalgia/
Lack of or damaged prostaglandin leads to thrombosis.
Despite test evidence, doctors ignored for 2 years, my low cortisol. Further ignored existing VWF. How many people are tested for VWF, thrombosis and cortisol?
If you can, please read it all.
This is the second in a series of blogs on the IACFS/ME 2022 International Conference on ME/CFS (and long COVID). The last one focused on David Systrom’s Keynote address (https://www.healthrising.org/blog/2022/07/29/systrom-keynote-iacfs-me-conference-long-covid/. This one focused on an hour-long talk that kicked off the keynote session.
excerpt:
Chronic Fatigue Syndrome (ME/CFS) and Fibromyalgia Connection
Interest in the HPA axis – which regulates the production of cortisol – in ME/CFS dates back 30 years. While the cause of the low morning salivary cortisol was never identified, several problems in the HPA axis did pop up over time.
Several factors made the HPA axis and cortisol an obvious early choice. Cortisol’s regulation of the stress response, metabolism, the sleep-wake cycle, and in suppressing inflammation means it has the potential to affect many of the processes at play in ME/CFS and long COVID. While HPA axis work declined over time, in ME/CFS it never really stopped. One intriguing 2018 ME/CFS study linked epigenetic modifications in T-cells to an impaired response to glucocorticoid hormones, such as cortisol, in a subset of patients. Dr. Klimas’s model-generated protocol for Gull War Illness (GWI) and ME/CFS includes both an immune modulator (etanercept) and drug (mifepristone) that she hopes will reset the HPA axis.
https://www.healthrising.org/blog/2...ng-covid-factor-chronic-fatigue-fibromyalgia/
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