ChookityPop
Senior Member
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what is the best test for enterovirus? And is there a lab somewhere in europe that does it?
Is there anyway to try IFN Lambda now?
Is there anyway to try IFN Lambda now?
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But it's indeed interesting that they reach the exact same level. As if the former infected cells had a marker and the none infected cells don't
Question is if low dose treatments would be enough to eridate the virus and not only block replicationYeah, it's strange. Maybe viral RNA levels in each cell which is infected go down a lot during interferon therapy, but the RNA is not quite fully cleared from the cell, so then the viral RNA regrows back in the same cells once interferon therapy is over.
I's just frustrating that interferon therapy works so well for many enterovirus ME/CFS patients (approx 50% respond to interferon), but does not seem to permanently clear the virus, so patients relapse typically 4 to 14 months later (usually after a bout of heavy exertion, like going on a hiking vacation — that's how Chia's son relapsed from his interferon therapy).
By contrast, interferon therapy for chronic hepatitis C virus infection of the liver sometimes leads to complete eradication of the hep C virus. So it can cure hep C. Although I believe they give interferon for a longer period to hep C patients, like 12 months. Whereas in ME/CFS studies and in Chia's experiments, I think it was more like 3 months.
Maybe if ME/CFS patients took interferon for a year, it might lead to eradication of enterovirus. Though you generally feel terrible during interferon therapy, so taking it for a year would be some commitment.
An alternative idea I had that might prevent the ME/CFS relapse that occurs after interferon therapy is taking low-dose interferon forevermore, once regular interferon therapy has placed you in remission or near remission.
Normally you cannot take interferon by injection indefinitely, as even with low-dose interferon, your body eventually starts making anti-interferon antibodies, which unfortunately then disable the injected interferon.
But if you take low-dose interferon by a suppository rather than injection, these antibodies do not appear. So I was thinking that a low-dose interferon suppository maintenance dose taken indefintely could prevent relapse after the normal 3 month course of interferon therapy to treat ME/CFS. More info on interferon suppositories in this post.
Question is if low dose treatments would be enough to eridate the virus and not only block replication
Yes ok, would be interesting to know. Perhaps with adequate pacing possible.I would doubt that low-dose interferon could eradicate enterovirus from ME/CFS patients.
But if you substantially reduced the enterovirus infection with a course of injectable interferon (like Dr Chia sometimes uses), and this puts you in near remission, I wonder if taking daily interferon suppositories would prevent relapse back into ME/CFS, and thus help maintain the gains you made during the course of injectable interferon.
Interferon suppositories bought from Russian online prescription-free pharmacies are inexpensive.
By contrast, interferon therapy for chronic hepatitis C virus infection of the liver sometimes leads to complete eradication of the hep C virus.
That is an extraordinarily rare outcome- perhaps 1% of patients.
Interferon injections had a cure rate of about 40 to 50 percent.
Newer pill treatments have cure rates of nearly 100 percent. In clinical trials, Harvoni, for example, achieved a cure rate of about 94 percent after 12 weeks. Other drugs and combination medications had similarly high cure rates in that same time frame.
Just did some Googling on this, and found an article which says:
That article quotes an FDA release, which was apparently referring to the combination of Interferon with Ribavirin, although the FDA article did not make that clear as it should have.
I think this may be the case.Yeah, it's strange. Maybe viral RNA levels in each cell which is infected go down a lot during interferon therapy, but the RNA is not quite fully cleared from the cell, so then the viral RNA regrows back in the same cells once interferon therapy is over.
IFN alpha can't take down RNA enteric viruses on its own, not in the epithelial cells of the small intestine.
Article from 2011, shows Type I IFN (IFN alpha, beta, etc) is not enough to compensate for lack of Type III IFN (lambda) in rotavirus infection in gastrointestinal tract.
IFN-λ determines the intestinal epithelial antiviral host defense
I was thinking of a combo treatment w/ lambda as well. alpha or beta. or w/ something else like the ribivarin.That's interesting. So maybe one of these interferon combo treatments would work best, like say interferon beta + interferon lambda.
Yea, that's the same group of Swedes that did this 2021 articleThe first time I became aware of this newly-discovered interferon lambda was via this paper, which says that coxsackievirus B specifically blocks interferon lambda release, by blocking TLR3 and MDA5/RIG-I.
What about getting lots of people to send the info to his email or something and hope for the best?If only someone could show Dr. Chia the latest on IFN lambda and its potential for treating persistent enterovirus in CFS, he may be convinced to ask Eiger Pharmaceuticals for a small trial on their Pegylated Interferon Lambda. Plus it's in Phase III, they don't have much to lose from a small trial like that. It's all about convincing the one research scientist that might be interested.
How low dose are we talking? And what would it cost ish do you think?Yeah, it's strange. Maybe viral RNA levels in each cell which is infected go down a lot during interferon therapy, but the RNA is not quite fully cleared from the cell, so then the viral RNA regrows back in the same cells once interferon therapy is over.
I's just frustrating that interferon therapy works so well for many enterovirus ME/CFS patients (approx 50% respond to interferon), but does not seem to permanently clear the virus, so patients relapse typically 4 to 14 months later (usually after a bout of heavy exertion, like going on a hiking vacation — that's how Chia's son relapsed from his interferon therapy).
By contrast, interferon therapy for chronic hepatitis C virus infection of the liver sometimes leads to complete eradication of the hep C virus. So it can cure hep C. Although I believe they give interferon for a longer period to hep C patients, like 12 months. Whereas in ME/CFS studies and in Chia's experiments, I think it was more like 3 months.
Maybe if ME/CFS patients took interferon for a year, it might lead to eradication of enterovirus. Though you generally feel terrible during interferon therapy, so taking it for a year would be some commitment.
An alternative idea I had that might prevent the ME/CFS relapse that occurs after interferon therapy is taking low-dose interferon forevermore, once regular interferon therapy has placed you in remission or near remission.
Normally you cannot take interferon by injection indefinitely, as even with low-dose interferon, your body eventually starts making anti-interferon antibodies, which unfortunately then disable the injected interferon.
But if you take low-dose interferon by a suppository rather than injection, these antibodies do not appear. So I was thinking that a low-dose interferon suppository maintenance dose taken indefintely could prevent relapse after the normal 3 month course of interferon therapy to treat ME/CFS. More info on interferon suppositories in this post.
How low dose are we talking? And what would it cost ish do you think?