Iritu1021
Breaking Through The Fog
- Messages
- 586
Hey, no worries and no need to be embarrassed. This is what we are all here for - to brainstorm ideas off each other and to get the discussion going. Many of us here (and in science world) have invested a lot of time and effort and feelings into theories that didn't hold out in the end - but that's all part of the process. I'm sure that all the knowledge you've gained and all the connections you've made in your brain will come in handy at some point later.Important!
Sadly, I have to inform you that I've found a critical flaw in this hypothesis. There are still many pieces to it which I would consider valuable ideas, but the whole no longer works together.
I have stated that "after activating the A1 receptors, a significant portion of this adenosine is actually brought into the cell by CNT2 transporters, and proceeds to activate AMPK. The exact mechanism by which it accomplishes that is not known, but my speculation is that it’s a different mechanism from the one AMP uses, and therefore serves as a fallback activation route in muscle exertion." - this is not fully correct. The andenosine is transported into the cells, and does activate AMPK, but the mechanism is not unknown. The adenosine turns into AMP, which activates AMPK in the usual manner. Meaning, this cannot be an alternetive, fallback activation route for AMPK in contracting skeletal muscle. Unfortunately, this is one of the very few places where an error like this means the whole hypothesis falls apart. The two halves of this hypothesis - the systemic part with the anti-beta2 antibodies, and the intracellular part, with the phospatidic acid - no longer fit together, as they were tied by this idea of adenosine constituting a fallback activation route.
This is fully my mistake, I missed an important part in one of my sources. I apologize terribly for wasting your time. The irony of working on this for half a year only to discover a critical flaw days after going public, would be funny to me if I wasn't so embarassed by this.
The above will be edited in at the beginning of the text of the hypothesis itself, and the untrue statement marked red.
Keep it up! As Thomas Edison put it: "I failed my way to success".