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Tarantula Spider Venom May Provide Pain Relief Without Side Effects Often Experienced With Opiate Use
- Thread starter Wally
- Start date
roller
wiggle jiggle
- Messages
- 775
the spider sedates their victim, but then ingests the "poison" itself.
whats the effect on the spider? sleeps after eating a prey?
whats the effect on the spider? sleeps after eating a prey?
@roller - I don’t know. But hopefully, if this treatment works you will not need to keep a tarantula in your medicine cabinet. 😳🕷🕸😁
kangaSue
Senior Member
- Messages
- 1,857
- Location
- Brisbane, Australia
Another means of getting pain relief is to use nitrates. Most research is into transdermal glyceral trinitrate patches but the analgesic properties of nitrates seem to fly under the radar of most of the medical profession.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017304/ Transdermal and Topical Drug Administration in the Treatment of Pain.
[Nitrates are mainly used in the treatment of ischemic heart disease. However, drugs forming this group also display analgesic and anti–inflammatory effects. It is known that exogenous nitrates stimulate the release of nitrogen oxide (NO) from endothelium cells. This substance is a very strong mediator in many systems, especially in the central and peripheral nervous systems.
It seems that NO exerts its action through the stimulation of an increase in the concentration of guanylyl cyclase, increasing the level of cGMP. NO may also activate sensitivity to ATP potassium channels and, in this way, activate pain relief in the periphery.
It was demonstrated that ointments or patches containing glycerol trinitrate (nitroglycerine) display analgesic efficacy in the following conditions: rheumatoid arthritis, ankylosing spondylitis, costochondritis, muscle–fascial pain, complex regional pain syndrome, bursitis, coccydynia, bone metastases, vulvodynia and venous leg ulcers.
There is data indicating that the local action of nitrates potentiates analgesic effects of “strong” opioids, which indicates that this effect is a result of nitrate absorption and because of their central mode of action. The use of nitrates may be especially useful in patients in whom, due to renal, liver, heart, and GI tract diseases, NSAIDs are contraindicated. The main adverse effect associated with a local application of nitrates is frequent headaches.]
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665823/ The effect of transdermal nitroglycerin on pain control in diabetic patients with peripheral neuropathy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017304/ Transdermal and Topical Drug Administration in the Treatment of Pain.
[Nitrates are mainly used in the treatment of ischemic heart disease. However, drugs forming this group also display analgesic and anti–inflammatory effects. It is known that exogenous nitrates stimulate the release of nitrogen oxide (NO) from endothelium cells. This substance is a very strong mediator in many systems, especially in the central and peripheral nervous systems.
It seems that NO exerts its action through the stimulation of an increase in the concentration of guanylyl cyclase, increasing the level of cGMP. NO may also activate sensitivity to ATP potassium channels and, in this way, activate pain relief in the periphery.
It was demonstrated that ointments or patches containing glycerol trinitrate (nitroglycerine) display analgesic efficacy in the following conditions: rheumatoid arthritis, ankylosing spondylitis, costochondritis, muscle–fascial pain, complex regional pain syndrome, bursitis, coccydynia, bone metastases, vulvodynia and venous leg ulcers.
There is data indicating that the local action of nitrates potentiates analgesic effects of “strong” opioids, which indicates that this effect is a result of nitrate absorption and because of their central mode of action. The use of nitrates may be especially useful in patients in whom, due to renal, liver, heart, and GI tract diseases, NSAIDs are contraindicated. The main adverse effect associated with a local application of nitrates is frequent headaches.]
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665823/ The effect of transdermal nitroglycerin on pain control in diabetic patients with peripheral neuropathy