Switch to turn off inflammation.

[Learner1]

Maybe there is more than one thing that can hit production of this.

From the OAT Interpretation Guide for Citric and Cis-aconitic acids:

If HIGH
Impaired metabolism due to toxic metals (Fl, Hg, As, Sb) OR low cofactors (Fe, GSH—
depleted in oxidative stress); OR high amounts of dietary citric acid; OR metabolic acidosis (if mildly increased cisaconitic acid but markedly increased citric acid).
High Citrate and Cis-aconitate can indicate arginine insufficiency for ammonia clearance
through the Urea Cycle
Consider supplementing with arginine
Rule out toxic metals; glutathione, N-acetylcysteine, Mg, or L-glutamine; consider anti-oxidants; rule out pancreatic insufficiency (can lead to metabolic acidosis from deficient bicarbonate).

If LOW
Low or high pyruvic acid or low acetyl CoA (from fatty acid oxidation)

 

[brenda]

Pyruvate 4.2 (<6.4)
Citrate >2.000 (56-987)
Cis-Aconitate 92 (18-78)

Any idea what these mean please?

 

[HTester]

It looks like itaconate is made in the TCA cycle. If Fluge and Mella are right about impaired pyruvate dehydrogenase (PDH) function in CFS, then itaconate could be low in CFS. Because the TCA cycle is slow from the impaired PDH

One of the nice things about the itaconate shunt theory is that impaired PDH is a direct consequence of the CoA sequestration caused by the shunt. You need CoA to run PDH. The theoretical chain of events would be Infection, IFNa, ACOD1, CAD, itaconate, CoA sequestration, decreased PDH flux and decreased fatty acid oxidation, forced fuel switch to amino acids, TCA cycle rewiring, energy inefficiency.

Then we need a mechanism to make it chronic. I have a bunch of candidates. We're testing the first one now.

 

[HTester]

There's a Single Nerve That Connects All of Your Vital Organs — And It Might Just Be the Future of Medicine

Every physiologist and every physician is aware of the vagus nerve and its importance. On the other hand, I've met a lot of biochemists who haven't a clue about the autonomic nervous system.

 

[Learner1]

decreased fatty acid oxidation,

Can you please explain why FAO is decreased? I had metabolic treadmill testing showing I was doing almost all glycolysis and very little FAO, yet no one has been able to tell me why, or what can be done about it.

 

[wabi-sabi]

@Learner1 Does this possibly have something to do with glycolysis vs fatty acid oxidation? I'm too brain dead to absorb it myself right now.

https://en.wikipedia.org/wiki/Randle_cycle

 

[Learner1]

@Learner1 Does this possibly have something to do with glycolysis vs fatty acid oxidation? I'm too brain dead to absorb it myself right now.

https://en.wikipedia.org/wiki/Randle_cycle

Yes, it does have to do with all of that. Good find. But the question is, why does inhibition of FAO happen, yes it's related to malonyl CoA, but why is that changing to inhibit FAO? Viruses? Immune system? Stress? Depletion of some resource?

 

[GreenEdge]

How to turn off inflammation.

 

[Marylib]

Best place to get questions like this answered may be Joshua Leiske (Lieske)? Sorry - he has a website and a discord channel. https://bornfree.life/