Supplements and Drugs That Reduce or Prevent PEM (Post-Exertional Malaise)
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triffid113
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Something new I found out - there is something called mitophagy and things like fasting or pomegranate induce it. It causes your system to destroy malfunctioning parts of mitochondria and rebuild them. It's autophagy targeted at mitochondria. They say malfunctioning mitophagy is found in alzheimer's, diabetes, complications, artherosclerosis, cancer... and FATIGUE. Some of the things that can induce mitophagy include tea (catechinic acid), pomegranate (urolithin), quercetin (apples), and resveratrol (grapes, wine, blueberries, cocoa...). Melatonin is also listed but the comments say it PROTECTS the mitochondria, so maybe something you do to protect the newly rebuilt mitochondria from a quick demise. Like the astaxanthin I mentioned above (another protectant). There are supplements to induce mitophagy now with an ingredient called robuvit, from oak:
https://www.iherb.com/pr/swanson-robuvit-french-oak-wood-extract-200-mg-30-veggie-caps/117983
https://www.iherb.com/pr/life-extension-energy-renew-200-mg-30-vegetarian-capsules/62213
urolithin (from oak, pomegranate):
https://www.iherb.com/pr/super-nutrition-urolithin-a-250-mg-60-liquid-veggie-capsules/142031
general autophagy (turns out it uses luteolin):
https://www.iherb.com/pr/life-extension-geroprotect-autophagy-renew-30-vegetarian-capsules/106215
and, what I take, luteolin from celery due to it normalizes my high blood pressure):
https://www.iherb.com/pr/nutricost-luteolin-100-mg-120-capsules/129419
(I'm not full of energy, but that trudging through life after covid is gone.).
Caveat: autophagy protects against cancer, unless you've already got it well-established - then it protects the deranged cancer cells.
One of the interesting tidbits I found (a non sequitor) is this: The intestinal epithelium is one of the most rapidly self-renewing tissues and needs a great amount of energy. Mitophagy, which can mediate the clearance of damaged mitochondria before they cause activation of cell death, is crucial for the homeostasis of the intestinal epithelium [8]. I have been having gut issues and have been concerned because my sensitive gut lining sometimes limits the things I could take for health. It looks like a sensitive gut lining is an early sign of mitrochondrial decline. It made me wonder if gut lining sensitivities are a big problem here?
https://www.iherb.com/pr/swanson-robuvit-french-oak-wood-extract-200-mg-30-veggie-caps/117983
https://www.iherb.com/pr/life-extension-energy-renew-200-mg-30-vegetarian-capsules/62213
urolithin (from oak, pomegranate):
https://www.iherb.com/pr/super-nutrition-urolithin-a-250-mg-60-liquid-veggie-capsules/142031
general autophagy (turns out it uses luteolin):
https://www.iherb.com/pr/life-extension-geroprotect-autophagy-renew-30-vegetarian-capsules/106215
and, what I take, luteolin from celery due to it normalizes my high blood pressure):
https://www.iherb.com/pr/nutricost-luteolin-100-mg-120-capsules/129419
(I'm not full of energy, but that trudging through life after covid is gone.).
Caveat: autophagy protects against cancer, unless you've already got it well-established - then it protects the deranged cancer cells.
One of the interesting tidbits I found (a non sequitor) is this: The intestinal epithelium is one of the most rapidly self-renewing tissues and needs a great amount of energy. Mitophagy, which can mediate the clearance of damaged mitochondria before they cause activation of cell death, is crucial for the homeostasis of the intestinal epithelium [8]. I have been having gut issues and have been concerned because my sensitive gut lining sometimes limits the things I could take for health. It looks like a sensitive gut lining is an early sign of mitrochondrial decline. It made me wonder if gut lining sensitivities are a big problem here?
triffid113
Skimming for the gist
- Messages
- 907
- Location
- Michigan
oops - above I think I meant malfunctioning mitochondria (not mitophagy).
I found an interesting article here when looking into something else... it says rhodiola can help the fatigue of chronic fatigue. It's not a scientific article, but rhodiola is what I take to stay positive...it's Mother's Little Helper. If you are happy people treat you better too. I recommend it highly, never had any benefit from ashwaghanda. Just did a search for which is better and found this: https://dailygem.com/blogs/news/ash...ndha vs.,people with chronic fatigue syndrome.
The relevant lines are these:
"RHODIOLA BENEFITS: SHARPENS THE MIND
When comparing ashwagandha vs. rhodiola, rhodiola is a go-to for those looking to improve overall mental energy. It's so potent that it even enhances energy in people with chronic fatigue syndrome. "
I do think part of it's making me happier is giving my brain more energy. I think rhodiola is a wonderful supplement for anxiety (adrenal help). I take Now brand and want to point out that it takes 3 days to work...however if you take 2 pills the first day it works faster. idk how it works for fatigue, but perhaps, worth a try?
I found an interesting article here when looking into something else... it says rhodiola can help the fatigue of chronic fatigue. It's not a scientific article, but rhodiola is what I take to stay positive...it's Mother's Little Helper. If you are happy people treat you better too. I recommend it highly, never had any benefit from ashwaghanda. Just did a search for which is better and found this: https://dailygem.com/blogs/news/ash...ndha vs.,people with chronic fatigue syndrome.
The relevant lines are these:
"RHODIOLA BENEFITS: SHARPENS THE MIND
When comparing ashwagandha vs. rhodiola, rhodiola is a go-to for those looking to improve overall mental energy. It's so potent that it even enhances energy in people with chronic fatigue syndrome. "
I do think part of it's making me happier is giving my brain more energy. I think rhodiola is a wonderful supplement for anxiety (adrenal help). I take Now brand and want to point out that it takes 3 days to work...however if you take 2 pills the first day it works faster. idk how it works for fatigue, but perhaps, worth a try?
Rhodiola helps with my fatigue and resilience, but also seems to worsen my already somewhat bad tachycardia. Wish I could find some way to take it without that, but reminds me I want to try ivabradine.
I’m going to the dentist next week – long drive – going to try diazepam and hope to snooze most of the way. Will report back.
Edit: No discernible effect from 5mg diazepam before and after drive. Maybe I should have taken more, but I didn’t want to risk it with a medication I haven’t taken before. Didn’t even feel sleepy.
I thought it might prevent DOMS, as it is supposed to be a muscle relaxant, and I get horrible DOMS from sitting still and from sitting in a different position, but no. (I thought I might be clenching my muscles unconsciously and it would reduce that.)
Since my dad got a smaller car and I put on 20kg of muscle due to a neuromuscular disorder, this has gotten even worse. The car has enough leg room, but feels so narrow and cramped side to side. There are not many places to stop and stretch out, and each stop adds 20 to 30 minutes to the travel time as you have to pull off the freeway.
DOMS article:
https://www.painscience.com/articles/delayed-onset-muscle-soreness.php
Edit: No discernible effect from 5mg diazepam before and after drive. Maybe I should have taken more, but I didn’t want to risk it with a medication I haven’t taken before. Didn’t even feel sleepy.
I thought it might prevent DOMS, as it is supposed to be a muscle relaxant, and I get horrible DOMS from sitting still and from sitting in a different position, but no. (I thought I might be clenching my muscles unconsciously and it would reduce that.)
Since my dad got a smaller car and I put on 20kg of muscle due to a neuromuscular disorder, this has gotten even worse. The car has enough leg room, but feels so narrow and cramped side to side. There are not many places to stop and stretch out, and each stop adds 20 to 30 minutes to the travel time as you have to pull off the freeway.
DOMS article:
https://www.painscience.com/articles/delayed-onset-muscle-soreness.php
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