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Study: Vitamin E (Alpha form) suppresses beneficial Gamma form...

dannybex

Senior Member
Messages
3,555
Location
Seattle
Stumbled across this today:

The results demonstrate that alpha vitamin E levels increased in proportion to the dose administered. However, at every dose of alpha vitamin E, gamma vitamin E concentration was significantly suppressed. No beneficial changes in surrogate markers of atherosclerosis were observed, consistent with the negative results of prospective clinical trials using alpha vitamin E.

Our results suggest that all prospective cardiovascular clinical trials that used vitamin E supplementation actually suppressed the beneficial antioxidant gamma isomer of vitamin E. No beneficial effects on several potential cardiovascular risk factors were observed, even when the vitamin E was supplemented with vitamin C. If a standardized preparation of gamma vitamin E (without the alpha isomer) becomes available, the effects of gamma vitamin E on atherosclerotic risk will warrant additional studies.

http://www.ncbi.nlm.nih.gov/pubmed/19303966

Almost all vitamin E sold contains mainly the d-alpha form, which according to the above is not only worthless, but potentially harmful. I'm going to try and find some "gamma-e" without the alpha...



http://www.ncbi.nlm.nih.gov/pubmed/19303966
 

alex3619

Senior Member
Messages
13,810
Location
Logan, Queensland, Australia
Hi dannybex, this has been known to biochemists for many years. Martin Pall pointed it out in his book. All forms of vitamin E compete with each other for absorption. Synthetic vitamin E has minimal effect, but actively competes for absorption with the more effective forms. High doses of synthetic vitamin E can therefore lower total bioavailable vitamin E. Bye, Alex
 

dannybex

Senior Member
Messages
3,555
Location
Seattle
Unfortunately, most of us aren't biochemists! :(

And I may have misread it, but it looks like even moderate doses ("at every dose") inhibit or lower bioavailable "e".

Thanks Alex,

d.
 

rwac

Senior Member
Messages
172
You could try tocopherol-free tocotrienols, which are very good antioxidants. Tocotrienols even help with POTS.
 

Chris

Senior Member
Messages
845
Location
Victoria, BC
Hi; Martin Pall knows this, and formulated a group of supplements with Allergy Research some years ago, still available and again in the news, one of which included the gamma form of E plus at least one tocotrienal; Google "Martin Pall / Allergy Research" and you will find lots of relevant stuff. Best, Chris
 

sflorence

Senior Member
Messages
134
Stumbled across this today:

The results demonstrate that alpha vitamin E levels increased in proportion to the dose administered. However, at every dose of alpha vitamin E, gamma vitamin E concentration was significantly suppressed. No beneficial changes in surrogate markers of atherosclerosis were observed, consistent with the negative results of prospective clinical trials using alpha vitamin E.

Our results suggest that all prospective cardiovascular clinical trials that used vitamin E supplementation actually suppressed the beneficial antioxidant gamma isomer of vitamin E. No beneficial effects on several potential cardiovascular risk factors were observed, even when the vitamin E was supplemented with vitamin C. If a standardized preparation of gamma vitamin E (without the alpha isomer) becomes available, the effects of gamma vitamin E on atherosclerotic risk will warrant additional studies.

http://www.ncbi.nlm.nih.gov/pubmed/19303966

Almost all vitamin E sold contains mainly the d-alpha form, which according to the above is not only worthless, but potentially harmful. I'm going to try and find some "gamma-e" without the alpha...



http://www.ncbi.nlm.nih.gov/pubmed/19303966


Did you ever end up finding this vitamin E? I have feeling that I have a genetic mutation that effects the levels of cholesterol and lipids in my blood. It is called FHBL (
hypobetalipoproteinemia)