Strong Hormonal Pattern CFS + (auto)immune problems?

OverTheHills

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Hi there

I'm kind of hoping that some of you medically/biologically aware people might have a hypothesis or two for me. Apologies if this is covered in another thread, I couldn't find it.

The Pattern: Every month, just before my period, my CFS symptoms suddenly improve drastically - I stop feeling physically fatigued, weak, foggy/mentally tired for about 1.5 days. Looking at the graphs this seems to coincide with the time when both female hormones are at their absolute minimum. I have other seasonal fluctuations as well so it took me a long time to spot this pattern. I've noticed some posts where people say their symptoms worsen after menopause, which is the opposite to me?

Relevant Medical History:
Some autoimmune stuff - fluctuating positive ANA results, confirmed endometriosis since teenage, Raynaud's.
Also severe Polymorphic Light Eruption, many allergies (nickel, lanolin,insect bites,moulds, pollens), and unexplained severe urticarias all long predating CFS.
Never had a particularly effective immune system (caught chicken pox and measles at the same time when young - then got chickenpox twice more) later on regular flu, severe colds. Breathlessness following on from viral infections (but its not asthma)
Never tolerated the pill. Made me feel tired!

My Questions:
Have I got some sort of autoimmune thing going on here, possibly to progesterone, or is it "just" ME.

I'm tempted to tackle a GP again about this but in the past trying to talk to GPs (how about trying a chemical menopause since I'm 49 anyway - get lost ) or Rheumatologists (its not Lupus or anything common and we don't believe in CFS so go away) is about as productive as talking to my cat. And less fun.

Anyone else have a pattern like this?

OTH
 

flybro

Senior Member
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Hi there

I'm kind of hoping that some of you medically/biologically aware people might have a hypothesis or two for me. Apologies if this is covered in another thread, I couldn't find it.

The Pattern: Every month, just before my period, my CFS symptoms suddenly improve drastically - I stop feeling physically fatigued, weak, foggy/mentally tired for about 1.5 days. Looking at the graphs this seems to coincide with the time when both female hormones are at their absolute minimum. I have other seasonal fluctuations as well so it took me a long time to spot this pattern. I've noticed some posts where people say their symptoms worsen after menopause, which is the opposite to me?

Relevant Medical History:
Some autoimmune stuff - fluctuating positive ANA results, confirmed endometriosis since teenage, Raynaud's.
Also severe Polymorphic Light Eruption, many allergies (nickel,lanolin,insect bites,moulds, pollens), and unexplained severe urticarias all long predating CFS. (Similar here hives, never severe but worse after sun),
Never had a particularly effective immune system (caught chicken pox and measles at the same time when young - then got chickenpox twice more) later on regular flu, severe colds. Breathlessness following on from viral infections (but its not asthma) same here again, asthma puffas made it worse, prednisone helped much.
Never tolerated the pill. Made me feel tired! same again, tired and bad tempered, emotionally distraught, same with all hormone stuff, my daughters are the same as well.

My Questions:
Have I got some sort of autoimmune thing going on here, possibly to progesterone, or is it "just" ME.

I'm tempted to tackle a GP again about this but in the past trying to talk to GPs (how about trying a chemical menopause since I'm 49 anyway - get lost ) or Rheumatologists (its not Lupus or anything common and we don't believe in CFS so go away) is about as productive as talking to my cat. And less fun.

Anyone else have a pattern like this?

OTH
I was failure to thrive from 6weeks old, until about 5 or 6.

My brother who had asthma, and excema, I also think he had ADHD & was dyslexic, he also always had sniffles, he had ulcers on his back when he was little, had many infections in his teens. Convulsions when he was a baby.

Once past 5/6 I was pretty good, highly unusual for me to get anything, until I had red flu age 10/11 I think, mind gladular fever at about 10/11/12.

Kidney and urine infections in my teens, and a couple of odd collapsing/feinting type things.

I had hysterectomy @ 28.

My alleries were sudden onset about 5/6 years ago, which was not long after a tetanus jab.

My health has declined rapidly over the last 4/5 years.
 

Athene

ihateticks.me
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Opposite effect

I get the exact opposite from you - drastic worsening of ME symptoms for about 5 days before my period. It improves pretty rapidly (in a day) once my period starts.
I also have high ANA titers.
I tend to get very high histamine and I know this interacts with estrogen, though I don't know the details. (Apart from the muiltiple allergies and urticaria you mentioned I get other histamine symptoms: Histamine causes headaches, sleep disturbance, gut problems inc. diarrhoea, the "tired but wired" feeling, low BP and tachycardia and many other CFS symptoms)
I also had no tolerance of the pill. Apart from feeling tired it made me basically go "psychotic". I've tried 3 types and they all did this. I turned into a nutter.
I don't know how any of this fits together but could it be useful to do a sticky poll to see how other women are affected before their period? Do you know how to set one up?
 

OverTheHills

Senior Member
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A Poll: Good Idea

I don't know how any of this fits together but could it be useful to do a sticky poll to see how other women are affected before their period? Do you know how to set one up?
Hi Athene and Flybro , and thanks for taking time to fill me in on your experiences. I get the impression that my pattern of "remission" just before my period is rather atypical for CFS. Everything I have read indicates that your pattern Athene - worsening just before periods is the usual thing.

I think the idea of a poll is a good one but:eek:
you have NO IDEA how little ability I have with this sort of thing.:ashamed:

Comes from being middle aged with no kids (Twitter? Facebook? Why?).

I will just ask in an embarrassed whisper.... who should I ask to help me set it up??

OTH