Hi Philip!
Wow! That's amazing information! Thank you so much for explaining this in a language I can understand with my poorly functioning brain! Never took Iodoral before. I'm going to check for an iodine test I can order but I'm on low budget at the moment.
So you are sensitive to chlorine too? I haven't looked into my introduction for a while and not sure if I mentioned this but in my puberty and early teens I was very athletic and attending to a school specialized in PE,taken to various athletic events etc. and were in top of everything but we had swimming classes and I was underperforming everytime and have been put in one group with girls because of my sluggish swimming performance,I got out of breathe very quickly and my muscles were hurting really bad.
I had no clue back then what was wrong with me but now I know it was the chlorinated water.Since a month I have a chlorine filter and my stomach doesn't hurt anymore and I can think a bit better.Overall I'm feeling 5-10% better mentally.
I'm afraid to take the methylation supplements yet.Tyrosine triggered panic attacks in me so I try to stay away from it.
It might have been accident but I'm really scared when it comes to trying out new supplements.
How do the methyl B-s make you feel?
Thank you for the invaluable information and good wishes!
Hi again,
to be honest I have had chronic urticaria intensely from age 16 to age 22, exacerbated by exposure to chlorinated water like in swimming pools. The eruptions were so painful at times my whole skin was burning and itching severely. Due to this I avoided all swimming pools like the plague for five years. The period where I drank a lot of green tea was also bad in terms of severity of the skin eruptions. I never connected the dots then, and since I chose to not follow advice from clueless dermatologists (giving strong steriods as "band-aid"), I silently fought on in my quest to find the etiology of my symptoms, while the hives remained a mystery for quite a few years. Inability to break down histamine and faulty methylation also plays a part here I think.
Given my methylation SNP, I can easily understand that I have a "detox bottleneck", but it will not necessarily explain why the hives would get more severe in direct exposure to halogens. I have lately gotten into Iodine supplementation and strangely enough, after weeks of Orthoiodosupplementation (with companion nutrients, as described in compendium), I notice this reeking and strange body odor. This is classic sign of bromide toxicity. So needless to say, IMHO I strongly suspect Halogen imbalance as a part of my "health equation". From "testimonials" online, I get the impression that unloading of halogens could last for a while. The competing halogens will cling to iodine receptors in the thyroid, interfering with iodine uptake.
Another area to explore: If exclusion of chlorine gave you relief and you can't recall being exposed to fluoride, "PST Enzyme" (Phenolsulfotransferase) could also be a culprit. In the DAN (defeat autism now) community, many parents report that their autistic children get red ears and rashes after swimming. Not sure whether you actually had this, or just felt tired and fatigued after swimming.
The PST Enzyme is tied to the transsulfuration part, since it needs sulfate to function correctly. So this also point towards faulty methylation
. This link provides a "case study":
http://healingautismandadhd.wordpress.com/2010/08/04/swimming-brings-him-to-tears/ (I am not sure if the symotoms mentioned describe what you have experienced though..)
Given your profile (COMT ++) you should be careful with methyl donors, so I understand your conservative supplementing strategy. However it could be beneficial to include a well rounded b complex to see if that could relieve you from the fatigue (by giving your starved mitochondria some fuel
).
http://www.iherb.com/Thorne-Research-B-Complex-12-60-Veggie-Caps/18126 has equal parts of methylcobalamin and adenosylcobalamin, and has ample amounts of b2 and b3 as well. If you do want to explore Iodine, this supplement would aid absorption of it. I am currently researching a lot here..
Although I feel that methylation should not be kickstarted, and it would be wise to take small prudent steps working out diet and gut/dysbiosis issues before upping the methylfolate and b12, I personally feel a huge relief when I take a co-enzymated B complex (providing methyl- or phosphorylated versions of B's). My mood gets brighter and food cravings disappear for instance. So this is a 'staple', dysbiosis or not
Phil