Spironolactone for viruses - personal experience gathering

MartinK

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Hey, I did 5 weeks with Spironolactone 25 mg as Dr. do Campo recommended. No side effects, blood work OK, diuretic effect unobserved. But, looks like this drug not work for me. I stopped it on Tuesday. Hope it will work for someone else! I would be happy!
 

Marylib

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I've been taking a half dose for a week and go full dose tomorrow. The diuretic effect seems to have stopped. Or at least I don't notice it after a week. I kind of like it, but we'll see how it goes. I have to send some blood work to my GP who seems to think I am new at this kind of thing. It seems a bit stimulating. I stopped my mestinon while I'm trying it. Do you mean testosterone @godlovesatrier? I can't remember your gender, but at my age, I don't really care about my libido anymore. I mean, it's great to have one, but I prefer being able to think and get out of bed. I'm sure the spirolactone is not helping my POTS, but...you can't have everything. Maybe it will keep more hair on my head. That's one of its off-label uses. Anti-androgen-hair loss-remedy.
 

Marylib

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Yeah, I get it. Hormones are a big deal @godlovesatrier. I'm continually telling my GP I feel better on hormone replacement therapy and she says "But you have a uterus! It could get endometrial cancer!" And I say - three words; Quality of Life. She still doesn't get it. Makes me want to wring her neck.
 

godlovesatrier

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Yeah. I'd have tried tagamet too but that's really bad for men. Seemingly ok for women to use it. Goldstein used to see improvements with some of his ME patients when they took that stuff.

Exactly Goldstein was the same! If the patient is already bedbound and suicidal then what does it matter?! They just want to be alive.

So what symptom improvements have you seen? Are you able to list them?

Thanks
 

Marylib

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@godlovesatrier I stopped the trial for now because I'm hoping to get my saline infusions going, as well as hormone replacement, etc. I felt a slight increase in energy -maybe it's the antiviral action. I keep track of the things I do respond well to - so it's on the plus column at the moment. The saline infusions would offset any fluid loss, though, as I said, the diuretic effect didn't last more than two weeks.
 

Marylib

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Will start the spirinolactone again soon - since I did like it once the increased urination went away on its own. As usual, my problem is being mobile and well enough to get to the lab to have the blood drawn for the tests my GP wants every 2 weeks. I've promised her I won't overdose on potassium rich foods. In the meantime, there was at one point some interest in this drug as a treatment or maybe prophylaxis for severe consequences of SARS CoV 2. Seems it competes with the virus when it tries to latch onto the ACE2 receptors. There are a few references here and there, like this one:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363620/