SOD2 mutation & persistent copper issues

datura

datura

Messages
56
Anyone have advice on how to manage a SOD2 mutation? I’ve had a serum copper deficiency for years, but high unbound copper (due to lack of ceruloplasmin). My serum zinc is low but RBC zinc is normal. I supplement with zinc, but it worries me because of my pre-existing copper deficiency. I’ve tried supplements with both zinc and copper, but they make me unbelievably nauseous. The only one that doesn’t upset my stomach is zinc picolinate, but it doesn’t contain copper. I’ve tried ionic copper, and it makes me nauseous and causes a full-blown panic attack. I don’t have Wilson’s disease.
 
linusbert

linusbert

Senior Member
Messages
1,707
sod2 is the manganese based enzyme. so manganese should it be, not zink?

i do not tolerate any copper, i am fine with dark chocolate which covers rda with just a few grams of raw cacao.
also am copper deficient.
maybe copper deficiency is a downstream problem, because SOD2 lacking, so other SODs do more work.

pioglitazone a diabetes drug helped me a lot, its upregulating PPAR gamma.
 
D

datadragon

Senior Member
Messages
433
Location
USA
Most here do not yet properly understand that ceruloplasmin requires Vitamin A, Zinc, and Magnesium and that the zinc and Vitamin A are lowered by the inflammation and infection state which can cause the deficiency. Copper is required to be attached to ceruloplasmin to be usable by the body for this and its many other functions, otherwise you can have plenty of copper intake but still be deficient at the same time due to the lack of ceruloplasmin to make it usable. Most are not low in copper intake but low in being able to produce ceruloplasmin allowing both unbound copper and iron to build up and potential deficiency at the same time

Zinc is also involved in vitamin A metabolism and vice versa. Iwould use this link to check serum copper and serum ceruloplasmin (the usable copper) and can calculate free copper levels unbound to ceruloplasmin using this link but this is a spot check at the time of the test only. This does not reflect any long term accumulation in the tissues that may have also been going on.
https://web.archive.org/web/2021030...ients-families/lab-tracker-copper-calculator/

Try retinol vitamin A. Ceruloplasmin, a copper-containing acute phase plasma protein, has been shown to be regulated by 13-cis retinoic acid, a metabolite of Vitamin A in rats https://www.ncbi.nlm.nih.gov/pubmed/3655940
Ceruloplasmin secretion-based drug screening identified all-trans retinoic acid (ATRA) and other active Vitamin A metabolites as promising candidates for rescuing Ceruloplasmin secretion. ATRA also alleviated reactive oxygen species (ROS) production induced by lipid accumulation in Wilsons Disease-specific hepatocytes. https://www.biorxiv.org/content/10.1101/2021.08.10.455792v1
 
linusbert

linusbert

Senior Member
Messages
1,707
for me its weird,
i have too low copper and too low coeruloplasmin, but high normal retinol in blood. zink is low normal. and magnesium kinda middle of the spectrum.
 
You must log in or register to reply here.
Back