SOD2 homozygote, what now? Potential treatment Pioglitazone?

[linusbert]

i always was wondering why this one certain diabetes drug made me feel so much better, its name is pioglitazone also known as actos.
i am SOD2 homozygote.

i did AI work today, and i found this:
https://selfhacked.com/blog/the-brain-fog-gene-rs4880-or-sod2/

PPAR Gamma is helping in SOD2 , so pioglitazone increases PPAR Gamma. its one of its main targets and functions.

so could be pioglitazone a potential treatment for SOD2 homozygotes?

 

[Dysfunkion]

I'm not sure what my SOD2 type is but apparently cinnamon also does this which helps me a lot, unlike anything else and I couldn't explain it after digging around so much but I'm wondering is this may be it. Stacking high dose vitamin C on top of it (I take 2 grams every morning now) has been a game changer for me which also scavenges SO. With this on my current supplement stack I hang around mild most of the time with some neuro-cognitive issues.

 

[Anish04]

Few questions . Do you have CFS according to fukuda criteria I mean do you have pem. 2nd what does if pioglitazone you used.
3rd on a scale of 1 to 10 how much you improved?

 

[linusbert]

i dont have cfs, i do have pem, 15-30mg , should have started with 15. doctors were overeager.
i cant do the scale, i only know that my exercise tolerance increased a lot, lets say instead of a bad day i have a good day. my glucose levels improved as did my liver values. but it only worked for a few month. then it was normal, i got worse when i didnt take it. i slowly got down from 30 to 15.. then 22,5 ... when i have a hard day i use 30mg as pem blocker

 

[Anish04]

i dont have cfs, i do have pem, 15-30mg , should have started with 15. doctors were overeager.
i cant do the scale, i only know that my exercise tolerance increased a lot, lets say instead of a bad day i have a good day. my glucose levels improved as did my liver values. but it only worked for a few month. then it was normal, i got worse when i didnt take it. i slowly got down from 30 to 15.. then 22,5 ... when i have a hard day i use 30mg as pem blocker

PEM only occurs in ME/CFS Or fibro. if you have pem then it's CFS/me Or fibro

 

[linusbert]

PEM only occurs in ME/CFS Or fibro. if you have pem then it's CFS/me Or fibro

i dont believe in CFS being a disease, i believe its a symptom group with many different diseases causing it, in my case a metabolic myopathy or mitochondrial disease might be the origin.
but a homozygote SOD2 plus a few other factors could also lead to mitochondrial dysfunction. sometimes you got 1 or 2 bad genes and its fine, but then comes another 3rd or environmental factors and the body is overwhelmed and declines.
despite many others with cfs, i did not get it out of nothing, i have problems since i was a kid. and it slowly got worse and worse.

 

[Anish04]

i dont believe in CFS being a disease, i believe its a symptom group with many different diseases causing it, in my case a metabolic myopathy or mitochondrial disease might be the origin.
but a homozygote SOD2 plus a few other factors could also lead to mitochondrial dysfunction. sometimes you got 1 or 2 bad genes and its fine, but then comes another 3rd or environmental factors and the body is overwhelmed and declines.
despite many others with cfs, i did not get it out of nothing, i have problems since i was a kid. and it slowly got worse and worse.

How, you found your root cause?

 

[linusbert]

How, you found your root cause?

not exactly, thats what doctors suspected, but they couldnt find exact disease. and they do not want to continue, tell me i shall do expensive gene testing, but insurance doesnt pay much and doctors actually do not know for what to look.
i did a private whole genome sequencing, and didnt find a exact cause, but a expert would need to analyse it.

 

[GhostGum]

i did a private whole genome sequencing, and didnt find a exact cause, but a expert would need to analyse it.

Are you aware of Hips thread about using B12 oils? The guy who makes those who is a biochemist I believe will analyse your data for free, last time I checked, he is typically just interested in peoples stories and maybe data as well. There is also a guy called Dr. Dan Purser who I follow on YT, he seems to have quite an extensive knowledge on these subjects and puts out a lot of content, on specific snps, supplements and such, he mentions SOD quite a bit. I am just slightly sceptical with the supplements he has and seems to push quite a bit, I am not sure you treat SOD with more SOD neither. But he might actually be worth considering a tele appointment with, or his staff, since overall they seem very genuine.

I am concerned about my SOD1 these days, as I seem to have more connective, muscular and signalling issues than ever, but haven't been pursuing what to do about it really neither.

 

[GhostGum]

God, I just found the prices for appointments with Dr. Dan, unreal

Guess for just about any doctor these days its probably not crazy though.

 

[Anish04]

I am trialing pioglitazone 15 mg. Bought 30 tablets. Here pharmacist give any medicine to patients.

 

[linusbert]

I am trialing pioglitazone 15 mg. Bought 30 tablets. Here pharmacist give any medicine to patients.

hope it goes good, remember its a diabetes medicine pushing down insulin resistence with potential side effects like gallbladder issues, weight gain, heart weakness etc.
i would not go above 15mg and if possible even go down to 7,5.