@
Bluebrid
Thanks for posting this information about the superoxide dismutase (SOD) mimetic
tempol (also called 4-hydroxy tempo), which is very interesting.
Tempol seems to have worked well for you.
Tempol has had a potent effect on your
fibroid symptoms — you noted reduced pain, no PMS symptoms, and less bleeding within a week of starting tempol, and later a complete disappearance of the fibroids (no longer seen on your ultrasound scan).
How long had you been taking tempol when you had the ultrasound scan in which you saw that the fibroids had shrunk down to nothing, by the way, Bluebrid?
Tempol also seems to have put your
scleroderma into remission, and promoted new
hair growth.
Plus tempol seems to have worked very well for your father's
Parkinson's disease.
Looking at studies on tempol, and on these various diseases, the following would seem to support what you observed:
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This report by Peter Proctor and Donna Rolling-Proctor (who is should be mentioned have intellectual property claims to tempol) documented that when 10 mg of tempol a day was given to one patient with
fibrocystic breast disease (which are like uterine fibroids, but located in the breast), within 1 or 2 weeks there was significant symptomatic relief and regression of palpable cysts, which was confirmed by mammography and ultrasonography.
What did your doctor say about the sudden disappearance of your fibroids, by the way?
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This study found that
scleroderma patients have autoantibodies to CuZn-SOD (SOD1) that inhibited SOD activity, and the study authors suggest that this autoimmune inhibition of SOD1 activity may play a role in the development of scleroderma fibrosis. So if low SOD1 is indeed playing a role in scleroderma, then this might explain why the SOD1, SOD2 and SOD3 mimetic tempol helped with your scleroderma.
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This study found that tempol restored the
hair growth cycle in psychological stress induced hair loss.
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This study demonstrated that tempol is neuroprotective in models of
Parkinson's disease.
The website detailing tempol is found here:
http://tempol.info You can subscribe to the newsletter on the home page. The links do not seem to be working properly on this website, but the following three pages of the website are of interest:
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Information on Tempol
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Sources for Tempol
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Information on Superoxide Dismutase (SOD)
Note that there are three types of SOD:
CuZn-SOD (SOD1) found almost exclusively within cells (in the cytoplasm).
Mn-SOD (SOD2) found exclusively to the mitochondria.
EC-SOD (SOD3) found exclusively to extracellular spaces outside cells.
By the way, are you aware of the supplement
Glisodin, which comprises the enzyme superoxide dismutase (SOD) linked to the gliadin protein from wheat, which allows the SOD to survive transit through the acid environment of the stomach. SOD is deactivated by stomach acid, so orally taken SOD supplements are normally ineffective; however, the gliadin protects the SOD from the acid.
GliSODin raised blood levels of SOD by 89% and increased catalase levels by 171%.
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Glisodin has been shown to be neuroprotective.
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However, I don't think Glisodin is able to protect mitochondria, as I don't think the SOD from Glisodin can get to the mitochondria like SOD2 can. Thus Tempol, which mimics SOD1, SOD2 and SOD3, would be superior to Glisodin in this respect.
I tried Glisodin myself a few years ago, but did not notice any benefits for my ME/CFS.