When I went into flow-blown CFS, I noticed that any mucous membrane immediately became subject to inflammation and infection. That includes gut, sinuses, throat. It is a constant battle to using salt water and the neti pot to keep the sinus infections at bay. Your observation is right on target though.
I think that is very right: all the mucus membranes, from those in your sinuses and nasal cavity, down to your throat, esophagus, stomach, and intestines, are all subject to inflammation once you have ME/CFS.
I guess this is to be expected, as respiratory viruses like enterovirus live and replicate primarily in the mucus membranes. Dr John Chia certainly found that the stomach mucus membranes of ME/CFS patients were loaded with enteroviruses.
When I caught the virus that eventually caused my ME/CFS, this virus also spread around my social circle, and the majority of people that caught this virus, even though they did not get ME/CFS, all developed chronic nasal/sinus congestion/inflammation (with these people getting thick mucus being produced all the time in the nasal cavity). Even now, nearly 10 years after this virus went around my social circle, these infected people all still have the same chronic nasal/sinus congestion. It is permanent.
I found my chronic nasal/sinus congestion and inflammation were strongly linked to my anxiety symptoms: whenever the inflammation in my nasal/sinus mucus membrane increased, my anxiety symptoms would shoot up.
I searched high and low for drugs or supplements that could reduce my nasal/sinus mucus membrane inflammation, and thus my anxiety.
The best anti-nasal/sinus inflammation supplements I found were these:
N-acetylglucosamine (NAG) 500 to 1000 mg once or twice daily (NAG significantly reduces the sinus inflammation created by this virus — it appears to act as a nasal/sinus decongestant — and NAG greatly reduces the general sense of inflammation you feel within the head).
Propolis 1000 mg twice daily.
Grape seed extract 300 mg daily.
Reishi 1000 mg twice daily.
Echinacea 1000 mg twice daily.
Cat’s claw 1000 mg twice daily.
Vitamin A 25,000 IU daily.
These supplements all helped to reduce anxiety as well as nasal/sinus inflammation — especially NAG, which has powerful effects.
More info on anti-nasal/sinus inflammation
here.