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    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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Single Off Switch for Pain


Senior Member

Researchers found some neurons in the amygdala that can dampen pain signals in other parts of the brain. From an ME perspective, maybe this means that ME makes those neurons work less well, making us experience pain in our bodies even though there's no physical cause. I do feel that sort of neuropathic pain when my ME is worse than usual.

I wonder how difficult it would be to test that hypothesis in ME patients having a 'painful' day.