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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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Yeah, I get Life Extension magazines, seemed like a good supplement to try, just haven't had the cash. Hopefully the near future!
Dr. Klimas told once that she does not recommend any supplements unless she has reviewed the research regarding their efficacy. I can only tell you that I have noticed a difference and that I have not had that happy experience since I was on Ampligen in 2012. Because of my circumstances here at home, I have to push myself far too hard on a regular basis and as a consequence, was almost always feeling bad. Life was hell as so many members on this forum know so well. I still have bad days but now I can get four days in a row of feeling well enough to function. When the bad days come, as they inevitably do, they are not as severe and I recover more quickly.
I went to the Life Extension store in Ft. Lauderdale and purchased the Mitochondrial Basics bottle for $33. I am taking two capsules a day. One as soon as I get up and the other around 11am. I will say that my natural killer cell level and activity were within normal limits before I started the mitochondrial supplement. I have been taking the Isoprinosine for two years for that purpose. I only take one tablet three times a day with weekends off. Dr. Rey at Nova does not want me to take a higher dose at this time. She said something about my inflammation markers being high.
Just FYI, the MitoQ lost its positive effect on me, after about 2 weeks. I'm trying to work out why that was.
One possibility is that prior to starting MitoQ I was injecting 100ng/week gc-maf, though I had stopped that about 2 weeks prior to starting the MitoQ. It's possible MitoQ only works well in me when combined with gc-maf. With gcmaf.eu now banned from distributing to the UK, I can't test this idea.
I recently tried a 3 week break, and can report I did feel some positive increase in energy when I had my first dose again, although it was not as strong as what I reported in the beginning of this thread.
Afraid I don't have anything new to add, I stopped taking MitoQ after it stopped working. Good luck with your experiment.I must report that the Mito Basics with PQQ has stopped working for me. I know the reason is because I was taking care of a terminally ill family member during September and October. It was very stressful for me as he required care both day and night. Then there was the funeral and friends and family from near and far coming to pay their respects. I have been bad again with symptoms for about a month. I did not stop the Mito PQQ during any of this time but after reading your post I think I will stop it for two weeks and see if there is any improvement when I begin it again. I called Life Extension and they suggested trying their Rybogen formula too. I am wondering if you have any new input.
Yeah, it's so hard to tell. I'm really worried if I load too much it might lose its effect, and I'll have to wait another 6 months before trying again.Thanks, even if the answer is disappointing.
I'm wondering if loading it over several days before stopping would help sustain the effect better.
Not so long ago I tried out the spin trap antioxidant tempol, which is a potent SOD2 memetic, but did not notice much benefit from it. However, I think I may try MitoQ.
I doubt this is very useful but I'm curious what it is.MB is a better and safer ROS scavenger than NAC, MitoQ, and mTEM
In our study, we compared MB with three other ROS scavengers, including a widely used general antioxidant NAC, and two mitochondrial-specific antioxidants, MitoQ, and mTEM, and found that MB was the most effective, mTEM was the next best at reducing mitochondrial ROS and promoting cell proliferation (Fig. 1). To our surprise, we observed no beneficial effects of NAC treatment and even adverse effects of MitoQ (Fig. 1). The discrepancy of our results with some previous reports might be due to the much longer-term treatments of NAC or MitoQ in this study than previous experiments11, 21, 33. As shown previously9, 10, 13, 14 and in Fig. 4, MB has been used in cells and animals for long-term experiments with little toxicity or irritation. Therefore, we suggest that MB is a much safer and more effective antioxidant than NAC, MitoQ, and mTEM for long-term application on skin fibroblasts.
Taking 2x 5mg MitoQ per day has significantly decreased my fatigue levels. The effect occured within a few hours of taking my first dose.
MitoQ is a form of ubiquinone specifically adapted to enter the mitochondria (with a factor 800 increase in absorption). Ubquinone is a form of CoQ10..
It is not simply a supplement, but a drug variant of CoQ10 that is designed to rapidly accumulate in the mitochondria and has completely different pharmacology to the CoQ10 naturally found in out mitochondria.