pibee
Senior Member
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..Doesn't this paragraph explain good possible cause that SFN is causing or at least contributing to a great extent to ME symptoms?
Especially the part where SFN is present in MS but hard to prove sometimes only on high res MRI when you search for it...
(MSRF= Multiple Sclerosis Related Fatigue , MFIS = Modifed Fatigue Impact Scale )
Autonomic symptom burden is an independent contributor to multiple sclerosis related fatigue (2018)
The contribution of the peripheral nervous system to MSRF is a controversial topic, but it has been suggested that sensory perception resulting from a complex integration of physiological, biochemical, and other sensory feedback from the periphery may contribute to MSRF [32]. Interestingly, we found a signifcant negative correlation between MFIS and sweat volume at diferent sites measured with QSART. QSART has traditionally been used as a marker of peripheral cholinergic postganglionic nerve afection, so it has mainly been used in the diagnosis of small fiber neuropathy. As MS is a central nervous system disorder, the results of our study can be interpreted in two ways: either QSART can detect central disorders of thermoregulation or the peripheral nervous system is also afected in MS. An argument for the former is a study which showed that QSART values can be abnormal even with preganglionic lesions [33]. An argument for the latter comes from several studies questioning whether MS is a pure central nervous system disorder. Jende and colleagues have demonstrated peripheral nerve lesions in pwMS in vivo by high-resolution MRI [34]. These lesions are defned by an increase in proton spin density and a decrease in T2 relaxation time, indicating changes in the microstructural organization of the extracellular matrix in peripheral nerve tissue in MS. Furthermore, it has also been suggested that pwMS may exhibit signifcant small fber damage, which is associated with neurological disability from MS [35, 36]. One of the main consequences of sudomotor dysfunction in MS is heat sensitivity, and it has been suggested that heat sensitivity in MS might contribute to premature fatigue either through passively induced rises in body temperature or through exercise [37]. The results of our study provide a possible pathophysiological explanation for this association, although we did not assess changes in body temperature in our patient group. Despite this theoretical background, the relationship between fatigue symptoms and dysautonomia in MS has received only minor interest.
full study
https://sci-hub.tw/10.1007/s10286-018-0563-6
Especially the part where SFN is present in MS but hard to prove sometimes only on high res MRI when you search for it...
(MSRF= Multiple Sclerosis Related Fatigue , MFIS = Modifed Fatigue Impact Scale )
Autonomic symptom burden is an independent contributor to multiple sclerosis related fatigue (2018)
The contribution of the peripheral nervous system to MSRF is a controversial topic, but it has been suggested that sensory perception resulting from a complex integration of physiological, biochemical, and other sensory feedback from the periphery may contribute to MSRF [32]. Interestingly, we found a signifcant negative correlation between MFIS and sweat volume at diferent sites measured with QSART. QSART has traditionally been used as a marker of peripheral cholinergic postganglionic nerve afection, so it has mainly been used in the diagnosis of small fiber neuropathy. As MS is a central nervous system disorder, the results of our study can be interpreted in two ways: either QSART can detect central disorders of thermoregulation or the peripheral nervous system is also afected in MS. An argument for the former is a study which showed that QSART values can be abnormal even with preganglionic lesions [33]. An argument for the latter comes from several studies questioning whether MS is a pure central nervous system disorder. Jende and colleagues have demonstrated peripheral nerve lesions in pwMS in vivo by high-resolution MRI [34]. These lesions are defned by an increase in proton spin density and a decrease in T2 relaxation time, indicating changes in the microstructural organization of the extracellular matrix in peripheral nerve tissue in MS. Furthermore, it has also been suggested that pwMS may exhibit signifcant small fber damage, which is associated with neurological disability from MS [35, 36]. One of the main consequences of sudomotor dysfunction in MS is heat sensitivity, and it has been suggested that heat sensitivity in MS might contribute to premature fatigue either through passively induced rises in body temperature or through exercise [37]. The results of our study provide a possible pathophysiological explanation for this association, although we did not assess changes in body temperature in our patient group. Despite this theoretical background, the relationship between fatigue symptoms and dysautonomia in MS has received only minor interest.
full study
https://sci-hub.tw/10.1007/s10286-018-0563-6
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