Severe Reaction To Niacin

[adreno]

I think you have been unnecessarily rude, arrogant and pedantic lately. I don't think you need to be all that to make a point.

Please remember that there are real people behind the postings, and they are ill, and some are very caring, like Sherlock is, and he hasn't posted at PR anymore after your rudeness, and I miss his contributions.

I guess I can be a bit impatient at times, but it wasn't my intention to scare sherlock away. If I did, then I'm sorry. I'll try to be more careful how I word myself.

Feel free to correct me if I am wrong, there is histamine release from taking niacin.

But blood histamine and skin flushing isn't the same thing. Niacinamide will raise blood histamine, but not cause flushing.

 

[Sidereal]

@adreno, you haven't been poppin' that mirtazapine, have you?

 

[dannybex]

The niacin flush is not mediated through histamine release, but prostaglandins.

Niacinamide however does increase histamine levels…

http://www.ncbi.nlm.nih.gov/pubmed/23426511

 

[jess100]

Most only flush only head and neck. Someone who flushes terribly has more going on than usual.[/QUOTE]


Can you explain what you mean that "more is going on"? Any ideas what that might be? I just took 100 mg of niacin (after a very bad flush with 500) and had a similarly bad flush extending to ankles and hands but especially bad on back and face, and backs of arms.
I have the 1298 mutation and I'm taking methlyfolate and methyl B12.