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Serum autoantibodies against epithelial cell adhesion molecules as disease biomarkers of EoE


Senior Member
Serum autoantibodies against epithelial cell adhesion molecules as disease biomarkers of eosinophilic esophagitis.
Dellon ES, Lin L, Beitia R, Moran TP, Qian Y.

Eosinophilic esophagitis is an allergic/immune-mediated disease where a Th2 response is triggered by food or environmental allergens.12 The incidence and prevalence of EoE have been increasing over the past two decades.3 Because endoscopy and biopsy are required for diagnosis and monitoring, health care costs related to EoE are significant. This article is protected by copyright. All rights reserved.

As the abstract is really not very enlightening here's a snippet from the full publication:
In conclusion, this analysis of samples from a prospective cohort of EoE cases and
controls, showed for the first time that anti-NC16A and -DSG3 IgG4 autoantibodies were
strongly associated with EoE. Anti-NC16A IgG4 not only had a high diagnostic utility for
EoE, but levels decreased significantly in EoE cases with a histologic response after topical
corticosteroid treatment. Given these findings, further evaluation of the diagnostic and
monitoring utility of anti-NC16A IgG4 in EoE is warranted, as is investigation of the role of
this autoantibody in EoE pathogenesis.


I thought this was interesting and worth posting here because 1. I have esinophilic esophagitis, 2. I know of other people with ME that also have eosinophilic gastro diseases (including EoE), 3. I heard Nancy Klimas mention once that she thought eosinophilic gastro diseases were overrepresented in ME patients, and 3. this is the first time I've seen autoantibodies mentioned in relation to EoE although I hadn't gone looking for research on them.