pattismith
Senior Member
- Messages
- 3,735
Many people here on PR end with a SFN + Seronegative Sjogren Syndrome diagnosis, so while I'm waiting for my lip + skin biopsy date (in August), I have some time to read a bit about it…
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Sjogren diagnosis mostly requires positivity to anti-SSA or anti-SSB antibodies, so seronegative SS (SNSS) is not so easily reached.
Here some recent findings about neurological damages in SS:
This 2020 study (about SFN in SS patients) found that non length dependent pattern SFN was far more prevalent in SS than length dependent pattern.
Some insight about the different SFN patterns quickly explained by Dr Oaklander:
- Length-dependent SFPN starts distally, spreads proximally (Distal axons are targeted)
- Non-length dependent SFPN is proximal or patchy (Neuron cell bodies in trigeminal or spinal ganglia are targeted)
And this other 2020 study found that "Anti‐SSA/Ro and anti‐SSB/La autoantibodies might cause dysfunction in nodal and internodal region of the axon and small nerve fibers; meanwhile, autoreactive antibodies in seronegative primary SS mainly affect small nerve fibers.
Thus, the underlying pathophysiology for the two types of primary SS is different."
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2016 table diagnosis criteria:
"The classification of primary Sjögren's syndrome applies to any individual who meets the inclusion criteria*; does not have any of the conditions listed as exclusion criteria**; and has a score of ≥4 when the weights from the five criteria in the table are summed."
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Sjogren diagnosis mostly requires positivity to anti-SSA or anti-SSB antibodies, so seronegative SS (SNSS) is not so easily reached.
Here some recent findings about neurological damages in SS:
This 2020 study (about SFN in SS patients) found that non length dependent pattern SFN was far more prevalent in SS than length dependent pattern.
Some insight about the different SFN patterns quickly explained by Dr Oaklander:
- Length-dependent SFPN starts distally, spreads proximally (Distal axons are targeted)
- Non-length dependent SFPN is proximal or patchy (Neuron cell bodies in trigeminal or spinal ganglia are targeted)
And this other 2020 study found that "Anti‐SSA/Ro and anti‐SSB/La autoantibodies might cause dysfunction in nodal and internodal region of the axon and small nerve fibers; meanwhile, autoreactive antibodies in seronegative primary SS mainly affect small nerve fibers.
Thus, the underlying pathophysiology for the two types of primary SS is different."
--------------------------------------------------------------------------
2016 table diagnosis criteria:
"The classification of primary Sjögren's syndrome applies to any individual who meets the inclusion criteria*; does not have any of the conditions listed as exclusion criteria**; and has a score of ≥4 when the weights from the five criteria in the table are summed."