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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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I'm going to bump this thread. My doc and I are having this very discussion right now, about FUT2 SNPs and gut issues.Has their been any research with regards to secretor status (I believe this is FUT2) and CFS? I wonder what the frequency of non-secretors is within the CFS community.
My impression from reading the quoted bits above is that they really don't know what they're talking about. They start by calling SNPs "genes" even when on the same gene, and say being homozygous is relevant without stating which homozygous version is problematic.Is Sterling onto something significant?
Thanks for the info! And clearer perspective!My impression from reading the quoted bits above is that they really don't know what they're talking about. They start by calling SNPs "genes" even when on the same gene, and say being homozygous is relevant without stating which homozygous version is problematic.
They also don't mention that the first SNP listed probably isn't relevant itself (it's a synonymous/silent mutation which results in no changes), but is in tight linkage disequilibrium with a SNP allele which results in premature termination of the protein being created. That premature termination from an A allele is extremely common, and about 25% of people are homozygous for it - over 30% in some Caucasian samples. And another 50% are heterozygous.
It's hard to believe that 25%-75% of the world needs the product being marketed to cure a problem which has not been found to exist in conjunction with those SNPs. Actual research for the specific mutation and information about FUT2 are at www.omim.org/entry/182100#0001 . Mostly AA is just protective against a norovirus and might be responsible for a ridiculously small increase in the risk of developing Crohn Disease.
It's also completely ridiculous to state that it is "obvious" that a substance is causing widespread mayhem, in the complete lack of any evidence to that effect. This is sounding like a commercially motivated message created by someone who has little understanding of any of the subject matter.