I know this was posted elsewhere, but there are a couple of interesting bits I thought should be highlighted.
Two new studies!!!
Part of the problem, skeptics say, is that the researchers didn't exactly replicate the Science paper. XMRV is a so-called xenotropic murine virus, which means it can no longer enter mouse cells but can infect cells of other species. (Murine means "from mice.") The researchers in the PNAS paper say the viral sequences they find are more diverse than that and resemble more closely the so-called polytropic viruses, which is why they adopted the term MLV-related virus, for murine leukemia virus. "Let's be clear: This is another virus. They did not confirm [Mikovits's] results," says retrovirologist Myra McClure of ICL, a co-author of one of the four negative studies.
Still, "in the grand scheme of things," the viral sequence found in the PNAS paper closely resembles those of XMRV, says Celia Witten, the director of FDA's Office of Cellular, Tissue and Gene Therapies, who was not an author of the paper herself but spoke on Lo's behalf. Witten adds that the data "support" the Science paper. Mikovitswho is "delighted" by the new papersays the difference is not important. In as-yet-unpublished results, her group finds more genetic diversity in the virus as well, she says.
Many of the main players in the controversy plan to attend a workshop organized by NIH on 7 and 8 September. Mikovits, who is on the scientific committee, says she has seen the abstracts of two presentations confirming her findings. "I think it will be fun," she says.