NotThisGuy
Senior Member
- Messages
- 312
Hi,
I found something odd about SAM-e which I can't quite explain.
The reactions people have to SAM-e (wether CFS or not) seems to be all over the place.
Some people feel better on it and others seem to get a lot of depression and anxiety.
I tried SAM-e myself and at first I felt good on it.
I had less allergic symptoms probably due less histamines and my mind was clearer. It was easier to think and express myself.
Than on the third day something hit me. Severe muscle fatigue. It was almost like in a crash but not quite like a crash. There was something different.
It might have been a phosphorus deficiency. I'm not completely sure about this but takin phosphorus made me feel better.
Anyways I read on this forum and found a post of someone saying, he only uses the SAM-e Tosylate disulfate.
Appearently SAM-e is very labile and unstable and to have it as a supplement there are 2 different stable forms on the market.
The SAM-e Tosylate disulfate with 68-80% SAM-e and the SAM-e Butanedisulfonate with to me unkown amount of SAM-e.
SAM-e Tosylate disulfate has only the S,S form of SAM-e which is the bioactive form.
Im not sure about what form is in SAM-e Butanedisulfonate.
Now I found this interesting study:
https://www.ncbi.nlm.nih.gov/pubmed/685755
Summery:
-mice where injected with 96% purity SAM-e and methylation was blocked
-mice where injected "pure SAM-e" from another source and methylation was not blocked
now the abstract is really terrible and I assume that the study probably was terribly designed. Would like to read the full study but can not find it anywhere.
So now I'm wondering if we possibly are missing something about SAM-e and methylation.
I dont think it would be possible for us to source "pure SAM-e" and I dont know of SAM-e with 96% purity would match SAM-e Butanedisulfonate.
They also dont state if they are using S,S SAM-e or R,S SAM-e but I'm wondering if people who react poorly to SAM-e might be the ones blocking their methylation somehow through SAM-e and I wonder if this could be undone by taking the right SAM-e.
As usual tagging @Hip who will hopefully know more about this but I'd be glead to hear all of you guys thoughts on this topic.
I found something odd about SAM-e which I can't quite explain.
The reactions people have to SAM-e (wether CFS or not) seems to be all over the place.
Some people feel better on it and others seem to get a lot of depression and anxiety.
I tried SAM-e myself and at first I felt good on it.
I had less allergic symptoms probably due less histamines and my mind was clearer. It was easier to think and express myself.
Than on the third day something hit me. Severe muscle fatigue. It was almost like in a crash but not quite like a crash. There was something different.
It might have been a phosphorus deficiency. I'm not completely sure about this but takin phosphorus made me feel better.
Anyways I read on this forum and found a post of someone saying, he only uses the SAM-e Tosylate disulfate.
Appearently SAM-e is very labile and unstable and to have it as a supplement there are 2 different stable forms on the market.
The SAM-e Tosylate disulfate with 68-80% SAM-e and the SAM-e Butanedisulfonate with to me unkown amount of SAM-e.
SAM-e Tosylate disulfate has only the S,S form of SAM-e which is the bioactive form.
Im not sure about what form is in SAM-e Butanedisulfonate.
Now I found this interesting study:
https://www.ncbi.nlm.nih.gov/pubmed/685755
Summery:
-mice where injected with 96% purity SAM-e and methylation was blocked
-mice where injected "pure SAM-e" from another source and methylation was not blocked
now the abstract is really terrible and I assume that the study probably was terribly designed. Would like to read the full study but can not find it anywhere.
So now I'm wondering if we possibly are missing something about SAM-e and methylation.
I dont think it would be possible for us to source "pure SAM-e" and I dont know of SAM-e with 96% purity would match SAM-e Butanedisulfonate.
They also dont state if they are using S,S SAM-e or R,S SAM-e but I'm wondering if people who react poorly to SAM-e might be the ones blocking their methylation somehow through SAM-e and I wonder if this could be undone by taking the right SAM-e.
As usual tagging @Hip who will hopefully know more about this but I'd be glead to hear all of you guys thoughts on this topic.