• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

    To become a member, simply click the Register button at the top right.

Roseolovirus-associated encephalitis in immunocompetent and immunocompromised individuals


Senior Member
Silicon Valley, CA
So, it seems to be a day for HHV-s.

Ongrádi, J., Ablashi, D.V., Yoshikawa, T. et al. J. Neurovirol. (2016). doi:10.1007/s13365-016-0473-0



The roseoloviruses, human herpesvirus (HHV)-6A, HHV-6B, and HHV-7, can cause severe encephalitis or encephalopathy. In immunocompetent children, primary HHV-6B infection is occasionally accompanied by diverse clinical forms of encephalitis.

Roseolovirus coinfections with heterologous viruses and delayed primary HHV-7 infection in immunocompetent adults result in very severe neurological and generalized symptoms. Recovery from neurological sequelae is slow and sometimes incomplete. In immunocompromised patients with underlying hematological malignancies and transplantation, frequent single or simultaneous reactivation of roseoloviruses elicit severe, lethal organ dysfunctions, including damages in the limbic system, brain stem, and hippocampus.

Most cases have been due to HHV-6B with HHV-6A accounting for 2–3%. The most severe manifestation of HHV-6B reactivation is post-transplantation limbic encephalitis. Seizures, cognitive problems, and abnormal EEG are common.

Major risk factors for HHV-6B-associated encephalitis include unrelated cord blood cell transplantation and repeated hematopoietic stem cell transplantation. Rare genetic disorders, male gender, certain HLA constellation, and immune tolerance to replicating HHV-6 in persons carrying chromosomally integrated HHV-6 might also predispose an individual to roseolovirus-associated brain damage.

At this time, little is known about the risk factors for HHV-7-associated encephalitis. Intrathecal glial cell destruction due to virus replication, overexpression of proinflammatory cytokines, and viral mimicry of chemokines all contribute to brain dysfunction.

High virus load in the cerebrospinal fluid, hippocampal astrogliosis, and viral protein expression in HHV-6B-associated cases and multiple microscopic neuronal degeneration in HHV-7-associated cases are typical laboratory findings. Early empirical therapy with ganciclovir or foscarnet might save the life of a patient with roseolovirus-associated encephalitis.

Human herpesvirus 6 and 7Post-transplant limbic encephalitisGlial cell destructionIntrathecal overexpression of proinflammatory cytokinesMonitoring CSF viral loadEmpirical ganciclovir and foscarnet therapy

....broke up that giant abstract into smaller chunks, otherwise unaltered.



Senior Member
You're very welcome! It seems so weird that two came up to do with HHVs today; and both discuss CFS.

Every "Positive" & "Negative" results is a Plus. IMO, it narrows the field & makes it less of a looking for a needle in a haystack.

My Positiv-o-meter has been going up slowly over the last few months. Hopefully, it's a parabolic curve but I will take a linear one, too.