keepontruckin
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https://www.sciencedaily.com/releases/2022/11/221128112926.htm
The team found that if these proteins are altered, they can cause rogue killer T cells to grow unchecked, resulting in enlarged cells that bypass immune checkpoints to attack the body's own cells.
The study also identified two specific receptor systems -- ways for cells to talk to one another -- that are linked to stress.
"Part of what's driving these rogue cells to expand as killer T cells is the stress-sensing pathways. There is a lot of correlation between stress, damage and ageing. Now we have tangible evidence of how that's connected to autoimmunity," Professor Goodnow says.
The team found that if these proteins are altered, they can cause rogue killer T cells to grow unchecked, resulting in enlarged cells that bypass immune checkpoints to attack the body's own cells.
The study also identified two specific receptor systems -- ways for cells to talk to one another -- that are linked to stress.
"Part of what's driving these rogue cells to expand as killer T cells is the stress-sensing pathways. There is a lot of correlation between stress, damage and ageing. Now we have tangible evidence of how that's connected to autoimmunity," Professor Goodnow says.