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RNase l enzyme defect deficiency?


Senior Member
U.S., Earth
This is very old news.

RNase L is an important enzyme in the interferon antiviral pathway.
Years ago, it was found that some ME patients had a shortened form of the RNAse L enzyme.
It was hypothesized that this shortened form was less active in fighting viruses, which made patients more susceptible to viral infections.

Further research suggested that this shortened form of RNase L occurred naturally in chronic inflammation, and actually was more active, not less active, than the longer version of the enzyme.