• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

    To register, simply click the Register button at the top right.

RNase l enzyme defect deficiency?


Senior Member
U.S., Earth
This is very old news.

RNase L is an important enzyme in the interferon antiviral pathway.
Years ago, it was found that some ME patients had a shortened form of the RNAse L enzyme.
It was hypothesized that this shortened form was less active in fighting viruses, which made patients more susceptible to viral infections.

Further research suggested that this shortened form of RNase L occurred naturally in chronic inflammation, and actually was more active, not less active, than the longer version of the enzyme.