I've been reading Jorgen Jelstad's very interesting blog post on Rituximab from last October which includes some very interesting comments from Dr Nancy Klimas among other things, and a link to this 2009 article on how "rebooting" the immune system has helped in MS and rheumatoid arthritis, and might help in ME/CFS (this is the work that led to the Fluge & Mella study. It's also interesting how what was initially a very unpopular hypothesis by a couple of cold-shouldered researchers became mainstream.