here are some of my notes on histamine... some of this info overlaps w yours, but there is additional info that you might find interesting... in particular, some of the counter effect agents and references.
2nd: SAM-e and Pancreatic Enzymes (Wobenzym or Vascyzyme) can help w inflammation (histamine-driven and other types of inflammation). I didn't see either of those in your extensive notes, but i skimmed so I might have missed it. Each of those supplements have been a big help to me at times, but neither is a magic cure that helps ALL the time. something to consider and perhaps try.
=TYPES OF HISTAMINE RECEPTORS
There are four types of histamine receptors in the body, and activating each receptor performs a different task.
- http://www.scielo.br/pdf/abd/v85n2/en_10.pdf
- H1 – blood vessel dilation, smooth muscle contraction of the bronchi and GI tract, stimulation of vagus nerve, increases histamine and arachidonic acid release, decreased AV node conduction of the heart, helps form nitric oxide, improves eosinophil function.
- H2 – stimulates nasal and intestinal mucosa, relaxes the LES, increases vascular permeability, stimulation of suppressor T cells, increases stomach acid production, reduces neutrophil and basophil function, increases lymphocytes, increases activity of NK cells.
- H3 – increases histamine in the brain as a neurotransmitter, suppresses norepinephrine release at parasympathetic nerve endings, stimulates nasal mucus, reduces bronchoconstriction and gastric acid.
- H4 – enhances the function of eosinophils (disease fighting white blood cells), mast cells, and neutrophils.
- Histamine H1 receptors: Smooth muscle and endothelial cells affecting skin; blood vessels
- effects: vascular permeability, bronchoconstriction, platelet aggregation
- counter effect agents: Benadryl, Claritin, Xyzal (levocetirizine) block activity of these receptors
- Histamine H2 receptors: Cells in the intestines control acid secretion, abdominal pain, and nausea; heart rate
- effects: heart rate & cardiac output; gastric secretion
- counter effect agents: Pepcid, Tagamet, Zantac
- Histamine H3 receptors: Central nervous system controlling nerves, sleep, appetite and behavior
- effects: neurotransmission
- counter effect agents: TBD
- Histamine H4 receptors: Thymus, small intestine, spleen, colon, bone marrow and white blood cells; inflammatory response
- effects: immunomodulation; chemotaxis; implicated in rheumatoid arthritis;
- counter effect agents: culturelle (downregulates receptor, and, therefore inflammation) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042653/
- The Role of Histamine H4 Receptor in immune and Inflammatory disorders: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697784/
- (l rhamnosus, l gasseri) substantially inhibited the release of inflammatory mediators such as TNF-α, IL-6, IL-1β, and IL-10 stimulated the treatment of RAW 264.7 macrophages with LPS. ...This means that Lactobacillus rhamnosus may be working at the very deep and fundamental level of gene activity and transcription,inhibiting the NF-Kappa B signaling pathway