Actually, the study I quoted was a combined in vitro and animal model study, and did not involve diabetes. But you are correct those were not ME/CFS studies. Has there been any done with D-ribose?
Something in the back of my brain regarding a conference I attended years ago believes studies have been done. I think Teitelbaum was connected somehow. But I could be mistaken that he was directly involved. I know he was the first to promote D-Ribose supplementation at the IACFS/ME conference in January 2007. I spoke with the Corvalen researcher at that conference regarding their findings, and it all tied back to lack of ATP production. Ribose was the missing link. But perhaps this is more of an issue for FMS than ME/CFS. I have both.
I will ask you the same question you asked me; based on what info? How do you know those enzymes are screwed up in ME/CFS? I have not seen any data on this.
These enzymes are screwed up in some of us through G6PD deficiency testing. If you lack G6PD, your body isn't going to convert enough glucose to ribose for ATP. Again, this might be more of an issue for FMS since G6PD problems correlate high with spectrum disorders. And spectrum disorders correlate high with FMS.
I do not personally feel well with D-ribose, and I've seen negative reports from others as well. Some do feel better on it. I leave it to everyone to supplement as they see fit, but I personally choose to avoid D-ribose.
If you don't feel better on ribose then you don't need it. I know I need it because of how much better I felt when doing ATP therapy years ago. It gave my muscles more energy and stamina. I didn't crash as hard with PEM after doing chores around the house.
Granted, D-Ribose isn't as good as IV ATP. But it's better than nothing. And that's the key. If you feel better on it then you probably need it.
I've never really thought about this before, but this discussion is helping me to realize that several things I do for my health, like D-Ribose and FIR sauna, are more beneficial for my FMS than my ME/CFS. Or at least it seems that way to me.
Perhaps too many therapies we all discuss on these boards are best suited for one disease over another, but we often don't make the distinction and end up conflating them all. And perhaps this is one of those therapies. Some are helped by D-Ribose while others are not. And it might simply be a matter of comorbidity mucking up the works.