"Mitochondrial dysfunction among Veterans with GWI may help explain, in part, the persistence of this illness for over 25 years."
Researchers say they have found the “first direct biological evidence” of damage in Veterans with Gulf War illness to DNA within cellular structures that produce energy in the body.
Thefindingsappeared in the journalPLOS Onein September 2017.
A study that focused on mitochondrial DNA (mtDNA) included 21 Veterans with Gulf War illness (GWI) and seven controls.
In blood tests, researchers observed more lesions and more mitochondrial DNA—that is, extra copies of genes—in Veterans with Gulf War illness, relative to controls without the illness, suggesting excess DNA damage. Lesion frequency gives a direct measure of DNA damage, while the increased number of mtDNA copies reflects a response to the damage.
Both lesion frequency and the number of mtDNA copies vary in response to environmental toxins and together provide a reading of overall mitochondrial health, according to lead researcher Dr. Mike Falvo, a health sciences specialist at the VA New Jersey Health Care System.
He notes that everyone experiences some level of mtDNA damage, perhaps due to aging and environmental exposures, such as air pollution. In the study, the mtDNA damage was 20 percent greater in the Veteran group, compared with a control group that included three Veterans without GWI and four non-Veterans.
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“Greater mtDNA damage is consistent with mitochondrial dysfunction, which may contribute to symptoms of GWI, as well as persistence of this illness over time,” the researchers write. “We interpret these findings as evidence that mitochondrial dysfunction is involved in the pathobiology of GWI.”
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