On the topic of exosomes and potential short-term treatments, two technologies I’ve been eyeing that I believe hold tremendous promise – potentially as “proof of principle” to temporarily treat M.E. patients; and also maybe helpful to bring our most severe patients back from the brink. IMO these could be viable for an M.E. clinical trial, to do big data evaluation on patients before/after cytokine and/or exosome adsorption.
a)
Cytosorb’s (CTSO) Cytosorb extracorporeal cytokine adsorber. American company that is going gangbusters in Germany especially, with the Cytosorb used in ICU’s to treat systemic sepsis. Still an early stage biotech, however with doubling year-over-year revenues. As a new poster, I can't post links yet, but will try to shortly. Or you can go to the Cytosorb website and check out their investor presentation and their Cytosorb user’s group (most active in Germany) that waxes poetic on the ability of this cartridge to filter out cytokines from the blood. Quite dramatic physiological responses in these critically ill ICU patients. If M.E. is so closely related to Systemic Inflammatory Response Syndrome and low-grade sepsis, maybe we're ideal candidates too?
b) Aethlon Medical’s Hemopurifier. Started off as an adsorber for viruses, now also targeting cancerous and non-malignant exosomes. You can google Seeking Alpha, and Aethlon for this filing. Will also try to post the link if my health allows later: "We are also investigating the ability of the Hemopurifier to capture glycosylated bacterial toxins and tumor-derived exosomes that promote cancer progression and treatment resistance. Additionally, we are the majority owner of Exosome Sciences, Inc. (ESI), a Company that is focused on the discovery of exosomal biomarkers to diagnose and monitor life-threatening disease conditions that may be current or future therapeutic targets for Aethlon Medical.
Do a search (Control “F”) in this document for “exosomes”, and take a look at all the patents they have on things like “methods for quantifying exosomes”; “methods for removal of exosomes”, etc.
FYI AEMD was one of Time Magazine’s feted ideas a couple of years ago. Lots of folks bought in, then the stock tanked again, so I'm posting from the clinical perspective, not with any investment advice

. IMO both of these early-stage biotechs have some maturing to do, but their products are fascinating, and potentially relevant for the M.E. arena.
Both of these technologies (CTSO and AEMD) require a dialysis machine.