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Reporting of Results in ClinicalTrials.gov and High-Impact Journals

Sea

Senior Member
Messages
1,286
Location
NSW Australia
Surprise surprise... these people found a high rate of discrepancy between what was recorded about a trial at ClinicalTrials.gov and what was actually published

Reporting of Results in ClinicalTrials.gov and High-Impact Journals

"The 2007 Food and Drug Administration (FDA) Amendments Act expanded requirements for ClinicalTrials.gov, a public clinical trial registry maintained by the National Library of Medicine, mandating results reporting within 12 months of trial completion for all FDA-regulated medical products. Reporting of mandatory trial registration information on ClinicalTrials.gov is fairly complete, although there are concerns about its specificity; optional trial registration information is less complete.1- 4 To our knowledge, no studies have examined reporting and accuracy of trial results information. Accordingly, we compared trial information and results reported on ClinicalTrials.gov with corresponding peer-reviewed publications."

http://jama.jamanetwork.com/article.aspx?articleid=1840223