Regulatory T Cells (auto-immunity) FOXP3- Mast Cell Activation

[kel88]

Hi There,

a couple of years ago I went to a good immunologist and they find I have low Regulatory T cells. I have many auto immune issues, and my only brother has Diabetes type-1.
so auto immunity is driving our family.

I did find out I have mutated FOXP3 genes.
(And very worse methylation genes).

I have one daugther. Did get her with ivf.
But did need high dose prednisolon , intralipid infusion, blood thinners to become pregnant. Because of my low Tregs. My immune system was so active that I couldn’t get pregnant.

Now I’m very curious about you’re genes!
Are they the same mutated as from me
And my Daugther? Maybe we share the same mutations what leads to CFS/ME.

so for the people who did a 23andme test.

the most important RS numbers for FOXP3 genes
(To make Regulatory T cells - wich lead to allergies and MCAD is thise
Are low)

Are:
RS3761548
RS2232365

** (less important I guess)
RS3761549

Hope we can share! I’m very curious!

 

[NotThisGuy]

RS3761548 T
RS2232365 C
rs3761549 G

what is considered normal and what mutated in those genes?

 

[kel88]

You are exactly my husband!
My husband has (undiagnosed Autism).
His sister had Asperger (very bad, -diagnosed and medication).
And our daugther has Autism.
There are many medical reviews to find.

RS 3761548 - is often found with MS, and more aggressive auto immune diseases. (TT allele)

RS2232365 is also often found with neuro diseases like Autism. (CC).

** it’s on the X chromosome. So man only has 1 mutation and women -2
Man are less prone to Auto immune disease because the have a higher Metabolism.
And some man hormones gives some higher Regulatory T cells.
I guess that’s the reason for all Auto immune diseases. It starts with FOXP3.
And the rest of your mutations diside wich auto Immun disease you will get. (Or not).

Regulatory T Cells are also involved in stopping viruses.
So low TREG cells will lead to chronic infections like EBV, but also Lyme , etc. Like many people with CFS/ME! So it starts here...

Boosting Tregs wil lead to less Allergies, Less Mast Cell issues so less Auto immunity.

Thanks for Sharing!
Hope some others will share to.
Maybe we find our connection.

 

[ShepherdK]

Myself (ME/CFS):
RS3761548: G
RS2232365: T
rs3761549: G

Wife (Healthy):
RS3761548: G/T
RS2232365: C/T
rs3761549: G/G

 

[kel88]

Thanks for sharing!
For now we only have the RS3761549 in common.
I guess it’s also the combination with methylation.
because METHYLATION defects blocks the liver and blocks metabolism. Wich lowers zinc uptake what is also needed for making proper TREG Cell.
Do you have Methylation issues ?
and you’re wife? Has she MTHFR mutations?

again thank you for sharing.
very interesting..

 

[wastwater]

I’m likely missing FOXC1 this has an effect on FOXO1A and that has an effect of FOXP3