The context is often not constructed by the therapist or the study alone, but also by the patient. This is commonly termed faith or belief. This can be nicely seen in our study on distant healing (Walach et al., 2008). We enrolled 409 patients with severe chronic fatigue syndrome into a study of distant healing. They either received distant healing immediately by three healers unknown to them and without any contact, or they had to wait for their treatment for six months. Again, half of the patients were informed about the group allocation, such that we had patients who were treated and knew about it, patients who waited and knew about it, and patients who were either treated or had to wait and did not know it. The overall result of the study did not provide any evidence that distant healing had an effect, except that all those groups that were either treated or did not know about their allocation had about one third of a standard deviation improvement over the control group that knew they had to wait for treatment. But the more interesting finding was the discovery that about 8%, 35 patients in all, had strong improvements. Analysing all those patients’ improvement that also provided data after a one year follow-up revealed that the decisive variable was not whether they were treated but whether they believed they were treated and received healing, whether true or wrong was irrelevant. Effect sizes were large and approached a standard deviation (d = 0.95). A qualitative post-hoc study using interviews revealed that most of these patients had made a leap of faith and at some point started to believe that something would happen (Güthlin, Anton, Kruse, & Walach, 2012). Thus, important parameters might reside in the patient’s consciousness. It is the meaning that triggers the meaning response.