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RCCX Theory and CDR (Naviaux)

Iritu1021

Breaking Through The Fog
Messages
586
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657867/

"Complex mixed states, defined as subsyndromal hypomanic symptoms co-occurring during a depressive episode (Benazzi, 2003) are very common and characteristic of individuals with BP II disorder (Benazzi, 2001a). From a clinical perspective, mixed moods are typically experienced as dysphoric, uncomfortable, energized states that one patient aptly described as “tired-wired.”
 

Iritu1021

Breaking Through The Fog
Messages
586
https://blog.frontiersin.org/2018/02/20/neuroscience-bipolar-disorder-biology-drug-treatment/

In a previous study by the group in 2016, one type of IEG gene known as EGR3, that normally responds to environmental events and stressful stimuli, was found to be repressed in the brain of BD patients. This suggests that when facing a stressor, the EGR3 in BD patients does not respond to the stimulus appropriately. Indeed, BD patients are highly prone to stress and have more difficulties dealing with stress or adapting to it if compared to healthy individuals. The research group is now suggesting that both EGR3 and BDNF may each play a critical role in the impaired cellular resilience seen in BD, and that each of these two genes may affect each other’s expression in the cell.

I have yet to speak to at least one person with CFS who used to be "a chill, laid back surfer dude" type prior to their illness. Let's face it - this illness (as well as its folk medicine counterpart known as "adrenal fatigue") is very much linked to stress and neuroticism.