SWAlexander
Senior Member
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- 1,670
I found this in my records:I was just checking that ALL your incidences of sepsis were directly after a surgery.
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I found this in my records:I was just checking that ALL your incidences of sepsis were directly after a surgery.
(CES) is compression of the spinal nerves and in my case, 7 existing Tarlov Cysts could be one reason.Arterial thromboembolism explain all the other symptoms in red
(CES) is compression of the spinal nerves and in my case, 7 existing Tarlov Cysts could be one reason.
I would appreciate your view.
The question remains why my hematologist did not see the connection. I´m facing a cycle of confusion, as I stated in the following post (Bernard-Soulier syndrome (BSS) high platelet numbers.
In fact, I am bruising very extensively and a cut wound bleeds for at least 2 hours if not pressured.
where as in post #64 you saidCholesterol-embolization syndrome (CES) is a multisystemic disease with various clinical manifestations. CES is caused by embolization of cholesterol crystals (CCs) from atherosclerotic plaques located in the major arteries, and is induced mostly iatrogenically by interventional and surgical procedures; however, it may also occur spontaneously.
(CES) is compression of the spinal nerves and in my case, 7 existing Tarlov Cysts could be one reason.
Yes it does. You make me rethink and reevaluate, even sometimes what "experts" come up with.hope its of some help
This is my major problem, confirmed herpes 1 and 2, rheumatoid arthritis, psoriatic arthritis, and lupus.chronic inflammatory disease
andComplement C4 is involved in the activation of both classical and lectin complement pathways. The classical pathway of complement system is crucial for anti-microbial defense through anti-pathogen antibody, which recruits C1 complex and initiates a cleavage cascade involving C4, C2, C3, and C5 and accomplishing microbial clearance. In addition, lectin complement pathway is also involved in the anti-microbial defense. Recent study revealed that loss of classical pathway results in rapidly progressing septicemia and impaired macrophage activation,
https://www.frontiersin.org/articles/10.3389/fimmu.2021.694928/fullA recent study by Liesmaa et al. demonstrated that homozygous C4A deficiency in patients was associated with the increased prevalence of lymphomas, celiac disease, and autoimmune disease SLE. In the same study, homozygous C4B deficiency in patients was documented to be linked with the drug intolerance and various post-infectious symptoms.
How thoughtful of you. Thank you.regarding immune suppression - resulting in repeated septicaemia against a background of problems with prior infections and i think auto-immune disease
i came across this in some of my reading today and your case came to mind
it points to deficiencies in the human complement system - namely C4 - being a known driver for susceptibility to both septicaemia and auto-immune diseases
Very clearly, we must rule out or include all possibilities.but i would be surprised if there wasn't something that is known to increase it nutritionally or epigenetically - even if a person has the less effective allele.