• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

    To register, simply click the Register button at the top right.

querying raw data in 23andme

ebethc

Senior Member
Messages
1,901
Can anyone tell me what "VERSION" means in 23andme?

In the Raw Data section, you can query a gene or SNP... The results show a table with the headers:
GENE, POSITION, SNP, VERSION, <NAME>'S GENOTYPE

So, for a particular gene BHLHE41 (with 3 snps) I got these results:

snp rs4963955, versions C or T, ebethc's genotype TT
snp rs4963956, versions C or T, ebethc's genotype CC
snp rs1480037, versions C or T, ebethc's genotype CC

Is the VERSION listed the bad result(s)? are BOTH C & T bad?
 
Messages
15,786
C and T are the alleles (variations). Usually neither version has any impact, or just has a very small impact.

If you want to know if an allele can cause problems you need to look up the research regarding that SNP. http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs= is the best site I'm aware of. And typically a variation has to result in a missense mutation or a stop-gain (changes in the protein created) to have any real impact.