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I wasn't sure what forum to put this in - ADD led me to choose this one as it's closer to the top.
I wonder if pycnogenol would inhibit XMRV, too? It's a potent radical scavenger, including of peroxynitrite, and also has some cognitive enhancing properties. Seems custom made for CFS. I tried it a few years ago and was intolerant to it because of some apparent alpha adrenergic effects (undoubtedly related to the reported ADHD benefit), but I might start trying it again at VLD (very low dose) and see if I can build up.
I wonder if pycnogenol would inhibit XMRV, too? It's a potent radical scavenger, including of peroxynitrite, and also has some cognitive enhancing properties. Seems custom made for CFS. I tried it a few years ago and was intolerant to it because of some apparent alpha adrenergic effects (undoubtedly related to the reported ADHD benefit), but I might start trying it again at VLD (very low dose) and see if I can build up.
Jpn J Infect Dis. 2008 Jul;61(4):279-85.
Pycnogenol, a procyanidin-rich extract from French maritime pine, inhibits intracellular replication of HIV-1 as well as its binding to host cells.
Feng WY, Tanaka R, Inagaki Y, Saitoh Y, Chang MO, Amet T, Yamamoto N, Yamaoka S, Yoshinaka Y.
Department of Molecular Virology, Graduate School, Tokyo Medical and Dental University, Tokyo 113-5819, Japan. 2yoshi.molv@tmd.ac.jp.
A procyanidin-rich extract from French maritime pine, Pycnogenol(R) (PYC), is known as an antioxidant that exerts a variety of physiological activities and is widely used in human beings. We report here that PYC inhibits not only human immunodeficiency virus type-1 (HIV-1) binding to host cells, but also its replication after entry in susceptible cells in vitro. Prominent biochemical alterations induced by PYC were the elevated expression of an intracellular antioxidant protein, manganese superoxide dismutase (Mn-SOD), and the inhibition of phosphorylation of the ribosomal S6 protein. Interestingly, ectopic expression of Mn-SOD inhibited HIV-1 replication as well. Inhibition of HIV-1 replication associated with induced expression of Mn-SOD in cells treated with PYC suggests the potential of this natural antioxidant inducer as a new anti-HIV-1 agent.
Pycnogenol, a procyanidin-rich extract from French maritime pine, inhibits intracellular replication of HIV-1 as well as its binding to host cells.
Feng WY, Tanaka R, Inagaki Y, Saitoh Y, Chang MO, Amet T, Yamamoto N, Yamaoka S, Yoshinaka Y.
Department of Molecular Virology, Graduate School, Tokyo Medical and Dental University, Tokyo 113-5819, Japan. 2yoshi.molv@tmd.ac.jp.
A procyanidin-rich extract from French maritime pine, Pycnogenol(R) (PYC), is known as an antioxidant that exerts a variety of physiological activities and is widely used in human beings. We report here that PYC inhibits not only human immunodeficiency virus type-1 (HIV-1) binding to host cells, but also its replication after entry in susceptible cells in vitro. Prominent biochemical alterations induced by PYC were the elevated expression of an intracellular antioxidant protein, manganese superoxide dismutase (Mn-SOD), and the inhibition of phosphorylation of the ribosomal S6 protein. Interestingly, ectopic expression of Mn-SOD inhibited HIV-1 replication as well. Inhibition of HIV-1 replication associated with induced expression of Mn-SOD in cells treated with PYC suggests the potential of this natural antioxidant inducer as a new anti-HIV-1 agent.