Welcome to Phoenix Rising!
Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
To become a member, simply click the Register button at the top right.
PPI's result in undigested food in your bowels. This is know to exacerbate, if not to cause, increased intestinal permeability.
I also would like to caution on this, of course you can always give this a try for a short period, but I would stay away from PPIs unless you have a confirmed and severe problem with too much stomach acid possibly also scarring the esophagus. When I had gut trouble (thought to be gastritis) back then 3 weeks of omeprazole made everything worse and also caused an overgrow of candida. I likely never had high stomach acid in the first place and eventually fixed my gut to 80% with totally different remedies. If you must reduce acid I think h2 blockers are a gentler approach.