promising gene editing tx for EBV, etc.

ebethc

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For instance, for Epstein-Barr virus, the researchers targeted EBNA1, a constitutively expressed gene in EBV-infected cells, and this, they reported, led to a 50 percent to 60 percent decline of latent EBV in their experimental cell line. When they added a second gRNA aimed at a separate part of EBNA1, they observed a 95 percent loss of EBV.

https://www.genomeweb.com/scan/crispr-strategy-herpesviruses
 

gbells

Improved ME from 2 to 6
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The current problem with prime gene editing is that it is limited to 44 base pairs. Typical viral base pairs for EBV and HSV6 are 150,000 base pairs. It would need to be improved to work for these viruses.